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    cc2d2a coiled-coil and C2 domain containing 2A [ Danio rerio (zebrafish) ]

    Gene ID: 570250, updated on 28-Oct-2024

    Summary

    Official Symbol
    cc2d2aprovided by ZNC
    Official Full Name
    coiled-coil and C2 domain containing 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2291
    See related
    Ensembl:ENSDARG00000090971 AllianceGenome:ZFIN:ZDB-GENE-030131-2291
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc03c12; wu:fc03c12
    Summary
    Acts upstream of or within photoreceptor cell outer segment organization. Located in photoreceptor connecting cilium. Is expressed in central nervous system; pronephric duct; and receptor cell (sensu Animalia). Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 9; Meckel syndrome 6; intellectual disability; and retinitis pigmentosa. Orthologous to human CC2D2A (coiled-coil and C2 domain containing 2A). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    NEW
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    Genomic context

    See cc2d2a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2191987..2256618)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2256261..2320948)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain-containing protein 3-like Neighboring gene C1q and TNF related 7 Neighboring gene pleckstrin homology domain-containing family G member 1 Neighboring gene uncharacterized LOC103909650 Neighboring gene uncharacterized LOC137489065

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General protein information

    Preferred Names
    coiled-coil and C2 domain-containing protein 2A
    Names
    sentinel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      2191987..2256618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296578.3XP_009294853.1  coiled-coil and C2 domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8M3B5V4
      Conserved Domains (3) summary
      pfam15625
      Location:693863
      CC2D2AN-C2; CC2D2A N-terminal C2 domain
      cl14603
      Location:11461182
      C2; C2 domain
      cl23765
      Location:502630
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. XM_009296579.3XP_009294854.1  coiled-coil and C2 domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A8M3ANC5
      Conserved Domains (3) summary
      pfam15625
      Location:693863
      CC2D2AN-C2; CC2D2A N-terminal C2 domain
      cl14603
      Location:11461182
      C2; C2 domain
      cl23765
      Location:502630
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. XM_009296580.3XP_009294855.1  coiled-coil and C2 domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY26
      Conserved Domains (3) summary
      pfam15625
      Location:693863
      CC2D2AN-C2; CC2D2A N-terminal C2 domain
      cl14603
      Location:11411177
      C2; C2 domain
      cl23765
      Location:502630
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    4. XM_003201161.5XP_003201209.2  coiled-coil and C2 domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      A0A8M1RP95
      Conserved Domains (3) summary
      pfam15625
      Location:693863
      CC2D2AN-C2; CC2D2A N-terminal C2 domain
      cl14603
      Location:11411177
      C2; C2 domain
      cl23765
      Location:502630
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    5. XM_009296581.3XP_009294856.1  coiled-coil and C2 domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      A0A8M3AV15
      Conserved Domains (3) summary
      pfam15625
      Location:674844
      CC2D2AN-C2; CC2D2A N-terminal C2 domain
      cl14603
      Location:11271163
      C2; C2 domain
      cl23765
      Location:483611
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    6. XM_068216822.1XP_068072923.1  coiled-coil and C2 domain-containing protein 2A isoform X6

      Related
      ENSDARP00000107405.2, ENSDART00000126768.3