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    tefa TEF transcription factor, PAR bZIP family member a [ Danio rerio (zebrafish) ]

    Gene ID: 30674, updated on 14-Nov-2024

    Summary

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    Official Symbol
    tefaprovided by ZNC
    Official Full Name
    TEF transcription factor, PAR bZIP family member aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-264
    See related
    Ensembl:ENSDARG00000039117 AllianceGenome:ZFIN:ZDB-GENE-990415-264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tef; tefb; tefbeta; zTEF[a]; wu:fa12f02; wu:fb11h02
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to light stimulus and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in liver; midbrain hindbrain boundary; muscle; pleuroperitoneal region; and visual system. Orthologous to human TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tefa in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19144833..19153224, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (19022959..19031359, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene aconitase 2, mitochondrial Neighboring gene PHD finger protein 5A Neighboring gene zinc finger CCCH-type containing 7Bb Neighboring gene chibby 1, beta catenin antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Instrument design and protocol for the study of light controlled processes in aquatic organisms, and its application to examine the effect of infrared light on zebrafish. Dekens MP, et al. PLoS One, 2017. PMID 28212399, Free PMC Article
    2. Light directs zebrafish period2 expression via conserved D and E boxes. Vatine G, et al. PLoS Biol, 2009 Oct. PMID 19859524, Free PMC Article
    3. Size-selective mortality induces evolutionary changes in group risk-taking behaviour and the circadian system in a fish. Sbragaglia V, et al. J Anim Ecol, 2021 Feb. PMID 33064849
    4. Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. Chaigne C, et al. PLoS Genet, 2024 Feb. PMID 38408087, Free PMC Article
    5. Regulation of per and cry genes reveals a central role for the D-box enhancer in light-dependent gene expression. Mracek P, et al. PLoS One, 2012. PMID 23236462, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TEF regulates light-induced transcription of DNA repair genes.
      Title: Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TEF transcription factor, PAR bZIP family member a
    Names
    thyrotroph embryonic factor a
    thyrotroph embryonic factor beta
    thyrotrophic embryonic factor a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431066.1 → NP_001417995.1  TEF transcription factor, PAR bZIP family member a isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX000473
      UniProtKB/TrEMBL
      A0A8M2B278

    2. NM_131400.2 → NP_571475.1  TEF transcription factor, PAR bZIP family member a isoform 2

      See identical proteins and their annotated locations for NP_571475.1

      Status: VALIDATED

      Source sequence(s)
      BX000473
      UniProtKB/TrEMBL
      A0A8N7UZK1, Q9W722
      Related
      ENSDARP00000057123.3, ENSDART00000057124.5
      Conserved Domains (1) summary
      cd14695
      Location:229 → 288
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      19144833..19153224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156136.4 → XP_005156193.1  TEF transcription factor, PAR bZIP family member a isoform X1

      See identical proteins and their annotated locations for XP_005156193.1

      UniProtKB/TrEMBL
      A0A8M2B252, O57673
      Related
      ENSDARP00000057124.4, ENSDART00000057125.5
      Conserved Domains (1) summary
      cd14695
      Location:216 → 275
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      368932..375637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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