U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    FAM120A family with sequence similarity 120 member A [ Homo sapiens (human) ]

    Gene ID: 23196, updated on 3-Nov-2024

    Summary

    Official Symbol
    FAM120Aprovided by HGNC
    Official Full Name
    family with sequence similarity 120 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:13247
    See related
    Ensembl:ENSG00000048828 MIM:612265; AllianceGenome:HGNC:13247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSSA; C9orf10; HBVPTPAP
    Summary
    Enables RNA binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon (RPKM 25.6), appendix (RPKM 19.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FAM120A in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (93451685..93566112)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105619097..105733519)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (96213967..96328394)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 829, pseudogene Neighboring gene uncharacterized LOC107987097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:96213447-96213996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28621 Neighboring gene Sharpr-MPRA regulatory region 4009 Neighboring gene family with sequence similarity 120 member A opposite strand Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96222857-96223356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96228924-96229490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:96244807-96245307 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr9:96271147-96271342 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:96273606-96273793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96337173-96337768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96337769-96338363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96350491-96350991 Neighboring gene Sharpr-MPRA regulatory region 10393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96360469-96361050 Neighboring gene PHD finger protein 2 Neighboring gene microRNA 548au Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96397750-96398479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:96405763-96406603 Neighboring gene keratin-associated protein 5-5-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96431943-96432456

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC111527, MGC133257

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol  
    located_in membrane PubMed 
    is_active_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    constitutive coactivator of PPAR-gamma-like protein 1
    Names
    family with sequence similarity 120A
    oxidative stess-associated Src activator
    oxidative stress-associated Src activator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286722.2NP_001273651.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001273651.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL353629, AW949787, BC075701, BC111736, BQ020345, BQ421167, D80005
      UniProtKB/Swiss-Prot
      Q9NZB2
      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_001286723.2NP_001273652.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001273652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AL353629, BC007879, BC075701, BC111736
      UniProtKB/Swiss-Prot
      Q9NZB2
      Conserved Domains (1) summary
      pfam16181
      Location:327407
      RelB_transactiv; RelB transactivation domain
    3. NM_001286724.2NP_001273653.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 3' exons but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AF214738, AL353629, BC075701, BC111736, CA310462, R40697
      Consensus CDS
      CCDS75859.1
      UniProtKB/Swiss-Prot
      Q9NZB2
      Related
      ENSP00000364538.3, ENST00000375389.7
      Conserved Domains (2) summary
      pfam16181
      Location:327407
      RelB_transactiv; RelB transactivation domain
      cl27975
      Location:330527
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    4. NM_014612.5NP_055427.2  constitutive coactivator of PPAR-gamma-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_055427.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL353629, AW949787, BC075701, BC111736, BQ020345, BQ421167, D80005
      Consensus CDS
      CCDS6706.1
      UniProtKB/Swiss-Prot
      A6NGU0, C4AMC6, O60649, Q14688, Q4VXF4, Q4VXF5, Q4VXG2, Q86V69, Q96I21, Q9NZB1, Q9NZB2
      Related
      ENSP00000277165.5, ENST00000277165.11
      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      93451685..93566112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518412.3XP_011516714.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011516714.1

      UniProtKB/Swiss-Prot
      Q9NZB2
      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. XM_011518413.3XP_011516715.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011516715.1

      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. XM_047423080.1XP_047279036.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X5

    4. XM_005251842.6XP_005251899.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005251899.1

      UniProtKB/TrEMBL
      A0A8V8TNY3
      Related
      ENSP00000514050.1, ENST00000698944.1
      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    5. XM_047423081.1XP_047279037.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X6

    6. XM_011518414.4XP_011516716.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011516716.1

      Conserved Domains (1) summary
      cl28905
      Location:5220
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    7. XM_047423082.1XP_047279038.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X7

    8. XM_047423083.1XP_047279039.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X8

    9. XM_047423084.1XP_047279040.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X9

    10. XM_011518416.4XP_011516718.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X10

      Conserved Domains (1) summary
      pfam16181
      Location:327407
      RelB_transactiv; RelB transactivation domain
    11. XM_047423085.1XP_047279041.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      105619097..105733519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362501.1XP_054218476.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X1

    2. XM_054362503.1XP_054218478.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X3

    3. XM_054362505.1XP_054218480.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X5

    4. XM_054362504.1XP_054218479.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TNY3
    5. XM_054362506.1XP_054218481.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X6

    6. XM_054362502.1XP_054218477.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X2

    7. XM_054362507.1XP_054218482.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X7

    8. XM_054362508.1XP_054218483.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X8

    9. XM_054362509.1XP_054218484.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X9

    10. XM_054362510.1XP_054218485.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X10

    11. XM_054362511.1XP_054218486.1  constitutive coactivator of PPAR-gamma-like protein 1 isoform X11

    External link. Please review our privacy policy.