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    AAD3 putative aryl-alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850471, updated on 7-Sep-2023

    Summary

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    Gene symbol
    AAD3
    Gene description
    putative aryl-alcohol dehydrogenase
    Primary source
    SGD:S000000704
    Locus tag
    YCR107W
    See related
    AllianceGenome:SGD:S000000704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aryl-alcohol dehydrogenase (NADP+) activity. Predicted to be involved in cellular aldehyde metabolic process. Orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2) and AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (313890..314981)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene NADP-dependent alcohol dehydrogenase Neighboring gene Rds1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae. Yang DD, et al. Appl Environ Microbiol, 2018 Jan 1. PMID 29079624, Free PMC Article
    2. A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, et al. Nat Commun, 2020 Jul 3. PMID 32620756, Free PMC Article
    3. Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real. Delneri D, et al. Genetics, 1999 Dec. PMID 10581269, Free PMC Article
    4. Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Delneri D, et al. Yeast, 1999 Nov. PMID 10572264
    5. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aryl-alcohol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative aryl-alcohol dehydrogenase
    NP_010032.1
    • Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      313890..314981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178814.1 → NP_010032.1  TPA: putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRA7, P25612
      UniProtKB/TrEMBL
      A0A8H4BST3, B5VF34, C8ZAZ3
      Conserved Domains (1) summary
      cd19147
      Location:17 → 335
      AKR_AKR9A3_9B1-4; Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25612.1

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