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    gcga glucagon a [ Danio rerio (zebrafish) ]

    Gene ID: 494052, updated on 12-Sep-2024

    Summary

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    Official Symbol
    gcgaprovided by ZNC
    Official Full Name
    glucagon aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010219-1
    See related
    Ensembl:ENSDARG00000079296 AllianceGenome:ZFIN:ZDB-GENE-010219-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gcg; glu; zgc:103616
    Summary
    Enables glucagon receptor binding activity. Acts upstream of or within response to starvation and type B pancreatic cell development. Predicted to be located in extracellular region. Is expressed in endocrine system; endoderm; gut; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gcga in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11617520..11626018, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11587838..11596336, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein) alpha v1 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene dipeptidyl-peptidase 4 Neighboring gene methyltransferase 21A, HSPA lysine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Yee NS, et al. Genesis, 2001 Jul. PMID 11477692
    2. Glucagon-like peptide-1 activates the adenylyl cyclase system in rockfish enterocytes and brain membranes. Mommsen TP, et al. Comp Biochem Physiol B Biochem Mol Biol, 1998 Sep. PMID 9972283
    3. Generation of a Transgenic Zebrafish Model for Pancreatic Beta Cell Regeneration. Pourghadamyari H, et al. Galen Med J, 2019. PMID 34466457, Free PMC Article
    4. Fish proglucagon genes have differing coding potential. Zhou L, et al. Comp Biochem Physiol B Biochem Mol Biol, 2004 Feb. PMID 14990222
    5. Metformin, beta-cell development, and novel processes following beta-cell ablation in zebrafish. Wyett G, et al. Endocrine, 2018 Feb. PMID 29274062

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glucagon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucagon receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucagon a
    Names
    GLP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008595.3 → NP_001008595.2  glucagon a isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CU463033, CU570889
      UniProtKB/TrEMBL
      A0A8M1N3Q5, F1RD10
      Related
      ENSDARP00000063132.4, ENSDART00000063133.5
      Conserved Domains (2) summary
      pfam00123
      Location:50 → 76
      Hormone_2; Peptide hormone
      cl23718
      Location:5 → 120
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_001271770.1 → NP_001258699.1  glucagon a isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      CU463033, CU570889
      UniProtKB/TrEMBL
      A0A0R4IS85, A0A8M1NZU1
      Related
      ENSDARP00000139130.1, ENSDART00000160085.2
      Conserved Domains (1) summary
      pfam00123
      Location:50 → 76
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      11617520..11626018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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