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    cacnb2b calcium channel, voltage-dependent, beta 2b [ Danio rerio (zebrafish) ]

    Gene ID: 558806, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cacnb2bprovided by ZNC
    Official Full Name
    calcium channel, voltage-dependent, beta 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-129
    See related
    Ensembl:ENSDARG00000055565 AllianceGenome:ZFIN:ZDB-GENE-050208-129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cacnb2a; CACNB2.2; im:7141271; si:dkey-32m20.2
    Summary
    Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport and chemical synaptic transmission. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cacnb2b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31462763..31513360)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31479544..31556241)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene collectin sub-family member 12 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Neighboring gene transmembrane protein 236 Neighboring gene si:ch211-106h4.4 Neighboring gene mannose receptor, C type 1b Neighboring gene uncharacterized LOC110438058

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The calcium channel beta2 (CACNB2) subunit repertoire in teleosts. Ebert AM, et al. BMC Mol Biol, 2008 Apr 17. PMID 18419826, Free PMC Article
    2. Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development. Chowanadisai W. PLoS One, 2014. PMID 25375179, Free PMC Article
    3. Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity. Chernyavskaya Y, et al. Dev Dyn, 2012 Apr. PMID 22274990
    4. Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Zhou W, et al. Dev Dyn, 2008 Dec. PMID 19035348
    5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-2b
    Names
    CAB2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423728.1 → NP_001410657.1  voltage-dependent L-type calcium channel subunit beta-2b isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR293515, CT027716

    2. NM_001423729.1 → NP_001410658.1  voltage-dependent L-type calcium channel subunit beta-2b isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR293515, CT027716
      Related
      ENSDARP00000109412.2, ENSDART00000130722.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31462763..31513360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224271.1 → XP_068080372.1  voltage-dependent L-type calcium channel subunit beta-2b isoform X3

    2. XM_068224272.1 → XP_068080373.1  voltage-dependent L-type calcium channel subunit beta-2b isoform X4

      Related
      ENSDARP00000104581.3, ENSDART00000123495.3

    3. XM_068224266.1 → XP_068080367.1  voltage-dependent L-type calcium channel subunit beta-2b isoform X1

    4. XM_068224268.1 → XP_068080369.1  voltage-dependent L-type calcium channel subunit beta-2b isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081748.2: Suppressed sequence

      Description
      NM_001081748.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_001166324.1: Suppressed sequence

      Description
      NM_001166324.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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