insrb insulin receptor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insrbprovided by ZNC
Official Full Name: insulin receptor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020503-4
See related: Ensembl:ENSDARG00000071524 AllianceGenome:ZFIN:ZDB-GENE-020503-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IRb; sb:eu666; si:dkey-6n3.1
Summary: Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within chordate embryonic development and developmental growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (10927871..11053148, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (10898189..11023466, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insra and Insrb exhibit diversified functions in maintaining glucose homeostasis in zebrafish.
Title: Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G66597 (e-PCR)
- UniSTS:230435

fk33c01.x1 (e-PCR)
- UniSTS:200839

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein autophosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin receptor b

NP_001116701.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123229.1 → NP_001116701.1 insulin receptor b precursor

See identical proteins and their annotated locations for NP_001116701.1

Status: PROVISIONAL

Source sequence(s)

BX666064, BX908744

UniProtKB/TrEMBL

B7SNG5, Q1LVG4

Related

ENSDARP00000096601.4, ENSDART00000105823.6

Conserved Domains (6) summary

cd05061
Location:982 → 1269

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:606 → 649

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:226 → 273

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:173 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:348 → 462

Recep_L_domain; Receptor L domain

pfam07714
Location:989 → 1256

Pkinase_Tyr; Protein tyrosine kinase