U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    map1lc3a microtubule-associated protein 1 light chain 3 alpha [ Danio rerio (zebrafish) ]

    Gene ID: 406466, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    map1lc3aprovided by ZNC
    Official Full Name
    microtubule-associated protein 1 light chain 3 alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2232
    See related
    Ensembl:ENSDARG00000033609 AllianceGenome:ZFIN:ZDB-GENE-040426-2232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77094
    Summary
    Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be located in membrane. Predicted to be active in autophagosome membrane. Is expressed in forerunner cell group; nervous system; neural tube; skeletal muscle; and tail bud. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See map1lc3a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (26609110..26615608)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (26371494..26377992)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 8 Neighboring gene dynein, light chain, roadblock-type 1 Neighboring gene EF-hand and coiled-coil domain containing 1 Neighboring gene cilia and flagella associated protein 92 (putative)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Induction of autophagy by amino acid starvation in fish cells. Yabu T, et al. Mar Biotechnol (NY), 2012 Aug. PMID 22290406, Free PMC Article
    2. Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Ganesan S, et al. Exp Cell Res, 2014 Oct 15. PMID 25051050
    3. Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling. Wen W, et al. Life (Basel), 2022 Aug 10. PMID 36013390, Free PMC Article
    4. Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Bello-Perez M, et al. Sci Rep, 2020 Jan 17. PMID 31953490, Free PMC Article
    5. The DNA methyltransferase DNMT3A contributes to autophagy long-term memory. González-Rodríguez P, et al. Autophagy, 2021 May. PMID 32876528, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3A
    Names
    microtubule-associated protein 1-light chain 3A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214739.1 → NP_999904.1  microtubule-associated proteins 1A/1B light chain 3A

      See identical proteins and their annotated locations for NP_999904.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067189
      UniProtKB/TrEMBL
      A1IIC2, Q6NX90
      Related
      ENSDARP00000042321.2, ENSDART00000042322.4
      Conserved Domains (1) summary
      cd17234
      Location:4 → 120
      Ubl_ATG8_MAP1LC3A; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3A (MAP1LC3A)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      26609110..26615608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.