rab1ab RAB1A, member RAS oncogene family b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab1abprovided by ZNC
Official Full Name: RAB1A, member RAS oncogene family bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-564
See related: Ensembl:ENSDARG00000029663 AllianceGenome:ZFIN:ZDB-GENE-030616-564
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RAS; RAB1B; rab1a; fb53a02; oncogene; wu:fb53a02; si:zc101n13.3
Summary: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be active in endomembrane system. Is expressed in brain; telencephalon; and testis. Orthologous to human RAB1A (RAB1A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (24402428..24411961)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (24271978..24281511)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 mutant embryos.
Title: Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.
Ras activity levels control the repopulation and expansion of adult melanocyte precursors after tissue loss, enabling the recovery of patterned melanocyte stripes during zebrafish appendage regeneration.
Title: Ras controls melanocyte expansion during zebrafish fin stripe regeneration.

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General gene information

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Markers

fb53a02.x1 (e-PCR)
- UniSTS:203298

fb34h03.x1 (e-PCR)
- UniSTS:190451

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-1A

NP_001007162.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007161.1 → NP_001007162.1 ras-related protein Rab-1A

See identical proteins and their annotated locations for NP_001007162.1

Status: PROVISIONAL

Source sequence(s)

BC050239

UniProtKB/TrEMBL

B2GTI9, Q7ZSZ0

Related

ENSDARP00000043001.5, ENSDART00000043002.6

Conserved Domains (2) summary

smart00175
Location:9 → 172

RAB; Rab subfamily of small GTPases

cd01869
Location:7 → 172

Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1