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    ZNF143 zinc finger protein 143 [ Homo sapiens (human) ]

    Gene ID: 7702, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF143provided by HGNC
    Official Full Name
    zinc finger protein 143provided by HGNC
    Primary source
    HGNC:HGNC:12928
    See related
    Ensembl:ENSG00000166478 MIM:603433; AllianceGenome:HGNC:12928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SBF; STAF; pHZ-1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF143 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9461012..9528524)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9546141..9612748)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9482559..9550071)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene Sharpr-MPRA regulatory region 11606 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9480928-9481563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3126 Neighboring gene ZNF143 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3127 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9537259-9537799 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9551203-9551929 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9584901-9585400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3128 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9594443-9595295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3131 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4411 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9622289-9622842 Neighboring gene ribosomal protein L23a pseudogene 65

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 143
    Names
    SPH-binding factor
    hStaf
    selenocysteine tRNA gene transcription-activating factor
    transcriptional activator Staf
    NP_001269585.1
    NP_001269586.1
    NP_003433.3
    XP_005253178.1
    XP_005253179.1
    XP_011518651.1
    XP_016873741.1
    XP_016873742.1
    XP_016873743.1
    XP_016873744.1
    XP_047283508.1
    XP_047283509.1
    XP_047283510.1
    XP_047283511.1
    XP_047283512.1
    XP_047283513.1
    XP_047283514.1
    XP_047283515.1
    XP_047283516.1
    XP_047283517.1
    XP_047283518.1
    XP_054225845.1
    XP_054225846.1
    XP_054225847.1
    XP_054225848.1
    XP_054225849.1
    XP_054225850.1
    XP_054225851.1
    XP_054225852.1
    XP_054225853.1
    XP_054225854.1
    XP_054225855.1
    XP_054225856.1
    XP_054225857.1
    XP_054225858.1
    XP_054225859.1
    XP_054225860.1
    XP_054225861.1
    XP_054225862.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282656.2NP_001269585.1  zinc finger protein 143 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AK297214, AK313330, BF515092, BG825506, CN295530
      Consensus CDS
      CCDS60720.1
      UniProtKB/TrEMBL
      E7EN86
      Related
      ENSP00000432154.1, ENST00000530463.5
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    2. NM_001282657.2NP_001269586.1  zinc finger protein 143 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK297214, BC014458, BF515092, BG825506, CN295530
      Consensus CDS
      CCDS60721.1
      UniProtKB/TrEMBL
      E7EN86
      Related
      ENSP00000379843.3, ENST00000396597.7
      Conserved Domains (5) summary
      COG5048
      Location:233291
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:208230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:282309
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:268383
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:51161
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    3. NM_003442.6NP_003433.3  zinc finger protein 143 isoform 1

      See identical proteins and their annotated locations for NP_003433.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK297214, AW162015, BC020219, BG825506
      Consensus CDS
      CCDS7799.2
      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
      UniProtKB/TrEMBL
      E7EN86
      Related
      ENSP00000379847.2, ENST00000396602.7
      Conserved Domains (5) summary
      COG5048
      Location:264322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313340
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:299414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:82192
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      9461012..9528524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427553.1XP_047283509.1  zinc finger protein 143 isoform X5

      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    2. XM_047427557.1XP_047283513.1  zinc finger protein 143 isoform X6

    3. XM_047427552.1XP_047283508.1  zinc finger protein 143 isoform X5

      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    4. XM_011520349.3XP_011518651.1  zinc finger protein 143 isoform X5

      See identical proteins and their annotated locations for XP_011518651.1

      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
      UniProtKB/TrEMBL
      E7EN86
      Conserved Domains (5) summary
      COG5048
      Location:264322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313340
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:299414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:82192
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    5. XM_047427556.1XP_047283512.1  zinc finger protein 143 isoform X6

    6. XM_047427559.1XP_047283515.1  zinc finger protein 143 isoform X7

    7. XM_005253121.2XP_005253178.1  zinc finger protein 143 isoform X1

      UniProtKB/TrEMBL
      E7EN86
      Conserved Domains (5) summary
      COG5048
      Location:279337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:328355
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:314429
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:97207
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    8. XM_005253122.2XP_005253179.1  zinc finger protein 143 isoform X2

      UniProtKB/TrEMBL
      E7EN86
      Conserved Domains (4) summary
      COG5048
      Location:278336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:327354
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:313428
      zf-C2H2_8; C2H2-type zinc ribbon
    9. XM_017018252.2XP_016873741.1  zinc finger protein 143 isoform X3

      UniProtKB/TrEMBL
      E7EN86
    10. XM_017018253.2XP_016873742.1  zinc finger protein 143 isoform X4

      UniProtKB/TrEMBL
      E7EN86
    11. XM_047427554.1XP_047283510.1  zinc finger protein 143 isoform X5

      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    12. XM_017018254.3XP_016873743.1  zinc finger protein 143 isoform X6

      UniProtKB/TrEMBL
      E7EN86
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    13. XM_047427560.1XP_047283516.1  zinc finger protein 143 isoform X7

    14. XM_047427555.1XP_047283511.1  zinc finger protein 143 isoform X5

      UniProtKB/Swiss-Prot
      A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    15. XM_017018255.2XP_016873744.1  zinc finger protein 143 isoform X6

      UniProtKB/TrEMBL
      E7EN86
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    16. XM_047427558.1XP_047283514.1  zinc finger protein 143 isoform X7

    17. XM_047427561.1XP_047283517.1  zinc finger protein 143 isoform X8

    18. XM_047427562.1XP_047283518.1  zinc finger protein 143 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      9546141..9612748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369870.1XP_054225845.1  zinc finger protein 143 isoform X1

    2. XM_054369871.1XP_054225846.1  zinc finger protein 143 isoform X2

    3. XM_054369872.1XP_054225847.1  zinc finger protein 143 isoform X3

    4. XM_054369873.1XP_054225848.1  zinc finger protein 143 isoform X4

    5. XM_054369881.1XP_054225856.1  zinc finger protein 143 isoform X6

    6. XM_054369876.1XP_054225851.1  zinc finger protein 143 isoform X5

    7. XM_054369877.1XP_054225852.1  zinc finger protein 143 isoform X5

    8. XM_054369880.1XP_054225855.1  zinc finger protein 143 isoform X6

    9. XM_054369884.1XP_054225859.1  zinc finger protein 143 isoform X7

    10. XM_054369878.1XP_054225853.1  zinc finger protein 143 isoform X5

    11. XM_054369875.1XP_054225850.1  zinc finger protein 143 isoform X6

    12. XM_054369885.1XP_054225860.1  zinc finger protein 143 isoform X7

    13. XM_054369879.1XP_054225854.1  zinc finger protein 143 isoform X5

    14. XM_054369882.1XP_054225857.1  zinc finger protein 143 isoform X6

    15. XM_054369883.1XP_054225858.1  zinc finger protein 143 isoform X7

    16. XM_054369874.1XP_054225849.1  zinc finger protein 143 isoform X5

    17. XM_054369886.1XP_054225861.1  zinc finger protein 143 isoform X8

    18. XM_054369887.1XP_054225862.1  zinc finger protein 143 isoform X8