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    csc1 FHA domain-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541013, updated on 18-Sep-2024

    Summary

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    Official Symbol
    csc1
    Official Full Name
    FHA domain-containing protein
    Primary source
    PomBase:SPBC3H7.13
    Locus tag
    SPOM_SPBC3H7.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    far10
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    Genomic context

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    See csc1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1859004..1861268, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene U3 snoRNP-associated protein Esf2 Neighboring gene beige protein 1 Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase (CK1 family) Hhp1 Neighboring gene ncRNA Neighboring gene BRCT domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RAVE complex subunit Rav2 Neighboring gene actin binding methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain. Willet AH, et al. Mol Biol Cell, 2024 Aug 1. PMID 38865179, Free PMC Article
    2. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Frost A, et al. Cell, 2012 Jun 8. PMID 22682253, Free PMC Article
    3. Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast. Miki F, et al. Mol Genet Genomics, 2004 Jan. PMID 14655046
    4. Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA. Zhang K, et al. Science, 2011 Mar 25. PMID 21436456, Free PMC Article
    5. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables spindle pole body anchor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization to old mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle pole body EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 

    General protein information

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    Preferred Names
    FHA domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1859004..1861268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021663.3 → NP_595762.1  FHA domain-containing protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595762.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74388
      Conserved Domains (2) summary
      COG1716
      Location:19 → 116
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:4 → 110
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials