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    VBA4 Vba4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851697, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VBA4
    Official Full Name
    Vba4p
    Primary source
    SGD:S000002526
    Locus tag
    YDR119W
    See related
    AllianceGenome:SGD:S000002526; FungiDB:YDR119W; VEuPathDB:YDR119W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable basic amino acid transmembrane transporter activity. Predicted to be involved in basic amino acid transport and transmembrane transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VBA4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (688227..690533)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tma64p Neighboring gene anaphase promoting complex subunit 4 Neighboring gene Cox26p Neighboring gene tRNA (guanine26-N2)-dimethyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Biosci Biotechnol Biochem, 2016. PMID 26325352
    2. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
    3. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article
    4. Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. Coelho MC, et al. Nature, 2019 Feb. PMID 30700905, Free PMC Article
    5. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vba4p is a vacuolar membrane protein that is involved in the drug resistance and vacuolar morphology in Saccharomyces cerevisiae.
      Title: Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vba4p
    NP_010404.1
    • hypothetical protein; proposed role as basic amino acid permease based on phylogeny; targeted to vacuole via AP-3 pathway; physical interaction with Atg27p suggests possible role in autophagy; non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      688227..690533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180427.1 → NP_010404.1  TPA: Vba4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA4, Q04602
      UniProtKB/TrEMBL
      C7GIM6, N1P877
      Conserved Domains (1) summary
      cl28910
      Location:259 → 414
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04602.1

    Gene LinkOut

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