U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cpa5 carboxypeptidase A5 [ Danio rerio (zebrafish) ]

    Gene ID: 246092, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cpa5provided by ZNC
    Official Full Name
    carboxypeptidase A5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020514-1
    See related
    Ensembl:ENSDARG00000021339 AllianceGenome:ZFIN:ZDB-GENE-020514-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cpa; cb1060; wu:fb68f03
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in blood; exocrine pancreas; liver; myeloid cell; and pancreas. Orthologous to several human genes including CPA1 (carboxypeptidase A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cpa5 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (18459928..18470695, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (18363528..18374295, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 41 Neighboring gene carboxypeptidase A1 (pancreatic) Neighboring gene testis derived transcript (3 LIM domains) Neighboring gene caveolin 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin. Sullivan-Brown J, et al. Nat Protoc, 2011 Jan. PMID 21212782, Free PMC Article
    2. Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Dobson JT, et al. Blood, 2008 Oct 1. PMID 18635811
    3. Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses. Da'as S, et al. Dev Comp Immunol, 2011 Jan. PMID 20849876
    4. Genetic analysis of early endocrine pancreas formation in zebrafish. Kim HJ, et al. Mol Endocrinol, 2006 Jan. PMID 16099813
    5. Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish. Qi F, et al. Hepatology, 2010 Dec. PMID 21064033, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Carboxypeptidase A5 (cpa5), a mast cell-specific enzyme, is expressed in zebrafish blood cells beginning at 24 hours post fertilization (hpf).
      Title: Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    carboxypeptidase A5
    Names
    carbA
    NP_954965.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199271.1 → NP_954965.1  carboxypeptidase A5 precursor

      See identical proteins and their annotated locations for NP_954965.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056300
      UniProtKB/TrEMBL
      A0A8M1PBE0, Q6PHV5
      Related
      ENSDARP00000034171.6, ENSDART00000034377.7
      Conserved Domains (2) summary
      pfam02244
      Location:27 → 100
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:118 → 417
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      18459928..18470695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools