smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smek1provided by ZNC
Official Full Name: SMEK homolog 1, suppressor of mek1 (Dictyostelium)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3958
See related: Ensembl:ENSDARG00000042187 AllianceGenome:ZFIN:ZDB-GENE-030131-3958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc60g09; wu:fc60g09; si:dkey-65b13.2
Summary: Orthologous to human PPP4R3A (protein phosphatase 4 regulatory subunit 3A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (33467161..33487741, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (33564282..33584862, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc60g09 (e-PCR)
- UniSTS:189468

fc25g06.x1 (e-PCR)
- UniSTS:193275

fc25g06.x1 (e-PCR)
- UniSTS:193276

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase 4 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 4 regulatory subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044809.1 → NP_001038274.1 serine/threonine-protein phosphatase 4 regulatory subunit 3

See identical proteins and their annotated locations for NP_001038274.1

Status: VALIDATED

Source sequence(s)

AL929220

UniProtKB/Swiss-Prot

Q5SP90

Related

ENSDARP00000061842.5, ENSDART00000061843.8

Conserved Domains (2) summary

pfam04802
Location:166 → 357

SMK-1; Component of IIS longevity pathway SMK-1

cl17171
Location:7 → 65

PH-like; Pleckstrin homology-like domain