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    slc13a5a solute carrier family 13 member 5a [ Danio rerio (zebrafish) ]

    Gene ID: 503788, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slc13a5aprovided by ZNC
    Official Full Name
    solute carrier family 13 member 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4628
    See related
    Ensembl:ENSDARG00000077691 AllianceGenome:ZFIN:ZDB-GENE-030131-4628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd44c11; slc13a5; im:7245905; wu:fd44c11; si:ch211-221p4.4
    Summary
    Predicted to enable citrate transmembrane transporter activity; sodium:dicarboxylate symporter activity; and succinate transmembrane transporter activity. Acts upstream of or within citrate transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to human SLC13A5 (solute carrier family 13 member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See slc13a5a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40053668..40083409, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40030115..40059896, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 47 member 2, tandem duplicate 2 Neighboring gene mediator complex subunit 31 Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Species-specific influence of lithium on the activity of SLC13A5 (NaCT): lithium-induced activation is specific for the transporter in primates. Gopal E, et al. J Pharmacol Exp Ther, 2015 Apr. PMID 25617245
    2. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540
    3. The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Lončar J, et al. Sci Rep, 2016 Jun 30. PMID 27357367, Free PMC Article
    4. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Shi X, et al. Blood, 2015 May 7. PMID 25778530
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:dicarboxylate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within citrate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fumarate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 13 member 5a
    Names
    NaCT
    info solute carrier family 13 (sodium-dependent citrate transporter), member 5
    info solute carrier family 13 (sodium-dependent citrate transporter), member 5a
    sodium-dependent citrate transporter
    solute carrier family 13 (sodium-dependent citrate transporter), member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142566.1 → NP_001136038.1  solute carrier family 13 member 5a

      Status: PROVISIONAL

      Source sequence(s)
      BX248108
      UniProtKB/TrEMBL
      A0A8M1NSQ7
      Related
      ENSDARP00000121887.2, ENSDART00000141160.3
      Conserved Domains (2) summary
      COG0471
      Location:43 → 559
      CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]
      cl21473
      Location:35 → 566
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      40053668..40083409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161432.5 → XP_005161489.1  solute carrier family 13 member 5a isoform X1

      UniProtKB/TrEMBL
      A0A2R8QQN0, A0A8M2B8B2
      Related
      ENSDARP00000157095.1, ENSDART00000191195.1
      Conserved Domains (2) summary
      COG0471
      Location:43 → 563
      CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]
      cl21473
      Location:35 → 570
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    Nucleotide Protein Strain
    Heading Accession and Version

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