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    RBA50 Rba50p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852139, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RBA50
    Official Full Name
    Rba50p
    Primary source
    SGD:S000002935
    Locus tag
    YDR527W
    See related
    AllianceGenome:SGD:S000002935; FungiDB:YDR527W; VEuPathDB:YDR527W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in transcription by RNA polymerase II. Located in cytoplasm. Orthologous to human RPAP1 (RNA polymerase II associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RBA50 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1491094..1492413)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Api2p Neighboring gene Sna2p Neighboring gene ncRNA Neighboring gene Hlr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. Jaime MD, et al. BMC Genomics, 2012 Jun 22. PMID 22727066, Free PMC Article
    2. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
    3. RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Jeronimo C, et al. Mol Cell Biol, 2004 Aug. PMID 15282305, Free PMC Article
    4. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
    5. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Alonso B, et al. Cell Cycle, 2013 Feb 1. PMID 23324351, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rba50p
    NP_010816.4
    • Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1491094..1492413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180835.4 → NP_010816.4  TPA: Rba50p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010816.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTE8, Q04418
      UniProtKB/TrEMBL
      A6ZZB4, B3LFE3, B5VH46, C8Z687, G2WBQ4, N1P945
      Conserved Domains (3) summary
      TIGR01612
      Location:62 → 289
      235kDa-fam; reticulocyte binding/rhoptry protein
      pfam08620
      Location:289 → 357
      RPAP1_C; RPAP1-like, C-terminal
      pfam08621
      Location:80 → 124
      RPAP1_N; RPAP1-like, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04418.2

    Gene LinkOut

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