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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011521.2 RefSeqGene
- Range
-
5049..54227
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001145392.2 → NP_001138864.1 tRNA-splicing endonuclease subunit Sen2 isoform 1
See identical proteins and their annotated locations for NP_001138864.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 6 encode the same isoform (1).
- Source sequence(s)
-
AC018500, AC090947, BC004178, BM671402
- Consensus CDS
-
CCDS2611.1
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
- UniProtKB/TrEMBL
-
A8K568
- Related
- ENSP00000385976.3, ENST00000402228.7
- Conserved Domains (2) summary
-
- pfam01974
Location:339 → 422
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:281 → 329
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
NM_001145393.3 → NP_001138865.1 tRNA-splicing endonuclease subunit Sen2 isoform 2
See identical proteins and their annotated locations for NP_001138865.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
- Source sequence(s)
-
AC018500, AK074794, BM671402, DA614108
- Consensus CDS
-
CCDS46757.1
- UniProtKB/TrEMBL
-
A0A7P0Z492
- Related
- ENSP00000416510.1, ENST00000415684.6
- Conserved Domains (2) summary
-
- pfam01974
Location:313 → 396
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- cl27367
Location:277 → 345
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
NM_001145394.2 → NP_001138866.1 tRNA-splicing endonuclease subunit Sen2 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
- Source sequence(s)
-
AC018500, AK225875, BM671402
- Consensus CDS
-
CCDS46758.1
- UniProtKB/TrEMBL
-
A8K568
- Related
- ENSP00000392029.2, ENST00000454502.6
- Conserved Domains (2) summary
-
- pfam02778
Location:224 → 270
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
- cd22363
Location:280 → 371
- tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
-
NM_001321277.2 → NP_001308206.1 tRNA-splicing endonuclease subunit Sen2 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 6 encode the same isoform (1).
- Source sequence(s)
-
AC018500, AK225875, BC004178, BM671402, DA614108
- Consensus CDS
-
CCDS2611.1
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
- UniProtKB/TrEMBL
-
A8K568
- Related
- ENSP00000505274.1, ENST00000679699.1
- Conserved Domains (2) summary
-
- pfam01974
Location:339 → 422
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:281 → 329
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
NM_001321278.2 → NP_001308207.1 tRNA-splicing endonuclease subunit Sen2 isoform 5
Status: REVIEWED
- Source sequence(s)
-
AC018500, AF086155, AK225875, BC004178, BE858588, DA614108
- Consensus CDS
-
CCDS93216.1
- UniProtKB/TrEMBL
- C9J7Z4, H7C2Z3
- Related
- ENSP00000406238.2, ENST00000446004.6
- Conserved Domains (4) summary
-
- COG1676
Location:297 → 425
- SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
- pfam01974
Location:339 → 422
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:281 → 329
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
- pfam13900
Location:450 → 497
- GVQW; Putative domain of unknown function
-
NM_001321279.2 → NP_001308208.1 tRNA-splicing endonuclease subunit Sen2 isoform 2
Status: REVIEWED
- Source sequence(s)
-
AC018500, AC090947, BC004178, BC019582, BM671402
- Consensus CDS
-
CCDS46757.1
- UniProtKB/TrEMBL
-
A0A7P0Z492
- Related
- ENSP00000506163.1, ENST00000681676.1
- Conserved Domains (2) summary
-
- pfam01974
Location:313 → 396
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- cl27367
Location:277 → 345
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
NM_025265.4 → NP_079541.1 tRNA-splicing endonuclease subunit Sen2 isoform 1
See identical proteins and their annotated locations for NP_079541.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 6 encode the same isoform (1).
- Source sequence(s)
-
AC018500, AC090947, BC019582, BM671402
- Consensus CDS
-
CCDS2611.1
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
- UniProtKB/TrEMBL
-
A8K568
- Related
- ENSP00000284995.6, ENST00000284995.11
- Conserved Domains (2) summary
-
- pfam01974
Location:339 → 422
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:281 → 329
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
RNA
-
NR_135607.2 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC018500, AF086155, AK027821, AK225875, BC004178, DA614108
- Related
-
ENST00000680923.1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12 Reference GRCh38.p14 Primary Assembly
- Range
-
12480231..12539624
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047449029.1 → XP_047304985.1 tRNA-splicing endonuclease subunit Sen2 isoform X2
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
-
XM_017007296.3 → XP_016862785.1 tRNA-splicing endonuclease subunit Sen2 isoform X2
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
- UniProtKB/TrEMBL
-
A8K568
- Related
- ENSP00000505799.1, ENST00000680986.1
- Conserved Domains (2) summary
-
- pfam01974
Location:339 → 422
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:281 → 329
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
XM_047449032.1 → XP_047304988.1 tRNA-splicing endonuclease subunit Sen2 isoform X5
-
XM_017007293.2 → XP_016862782.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
- A0A7P0T914, A8K568
-
XM_017007294.2 → XP_016862783.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
- A0A7P0T914, A8K568
-
XM_024453785.2 → XP_024309553.1 tRNA-splicing endonuclease subunit Sen2 isoform X5
- UniProtKB/TrEMBL
-
A0A7P0Z492
- Conserved Domains (2) summary
-
- pfam01974
Location:313 → 396
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- cl27367
Location:277 → 345
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
-
XM_017007292.2 → XP_016862781.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
- A0A7P0T914, A8K568
- Related
- ENSP00000505417.1, ENST00000680275.1
-
XM_047449030.1 → XP_047304986.1 tRNA-splicing endonuclease subunit Sen2 isoform X3
- UniProtKB/TrEMBL
-
A0A7P0T8F8
- Related
- ENSP00000505106.1, ENST00000680354.1
-
XM_047449031.1 → XP_047304987.1 tRNA-splicing endonuclease subunit Sen2 isoform X4
-
XM_047449033.1 → XP_047304989.1 tRNA-splicing endonuclease subunit Sen2 isoform X6
- UniProtKB/TrEMBL
-
A0A7P0TA86
- Related
- ENSP00000505979.1, ENST00000680458.1
-
XM_047449034.1 → XP_047304990.1 tRNA-splicing endonuclease subunit Sen2 isoform X7
- Related
- ENSP00000505351.1, ENST00000680765.1
-
XM_017007295.3 → XP_016862784.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
- A0A7P0T914, A8K568
-
XM_011534139.4 → XP_011532441.1 tRNA-splicing endonuclease subunit Sen2 isoform X8
- UniProtKB/TrEMBL
-
B7Z355
- Conserved Domains (3) summary
-
- COG1676
Location:206 → 334
- SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
- pfam01974
Location:248 → 331
- tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
- pfam02778
Location:190 → 238
- tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
RNA
-
XR_007095741.1 RNA Sequence
-
XR_007095740.1 RNA Sequence
-
XR_007095739.1 RNA Sequence
-
XR_001740289.3 RNA Sequence
- Related
-
ENST00000680449.1
-
XR_001740291.2 RNA Sequence
-
XR_002959592.2 RNA Sequence
-
XR_002959593.2 RNA Sequence
-
XR_007095737.1 RNA Sequence
-
XR_007095736.1 RNA Sequence
-
XR_007095742.1 RNA Sequence
-
XR_007095738.1 RNA Sequence
-
XR_007095743.1 RNA Sequence
-
XR_001740290.3 RNA Sequence
-
XR_007095750.1 RNA Sequence
-
XR_007095744.1 RNA Sequence
-
XR_007095747.1 RNA Sequence
-
XR_007095745.1 RNA Sequence
-
XR_007095749.1 RNA Sequence
-
XR_007095746.1 RNA Sequence
-
XR_007095748.1 RNA Sequence
-
XR_007095751.1 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1 Alternate T2T-CHM13v2.0
- Range
-
12478037..12537426
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054348034.1 → XP_054204009.1 tRNA-splicing endonuclease subunit Sen2 isoform X2
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
-
XM_054348031.1 → XP_054204006.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
-
A0A7P0T914
-
XM_054348032.1 → XP_054204007.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
-
A0A7P0T914
-
XM_054348038.1 → XP_054204013.1 tRNA-splicing endonuclease subunit Sen2 isoform X5
-
XM_054348030.1 → XP_054204005.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
-
A0A7P0T914
-
XM_054348036.1 → XP_054204011.1 tRNA-splicing endonuclease subunit Sen2 isoform X3
- UniProtKB/TrEMBL
-
A0A7P0T8F8
-
XM_054348037.1 → XP_054204012.1 tRNA-splicing endonuclease subunit Sen2 isoform X4
-
XM_054348040.1 → XP_054204015.1 tRNA-splicing endonuclease subunit Sen2 isoform X6
- UniProtKB/TrEMBL
-
A0A7P0TA86
-
XM_054348041.1 → XP_054204016.1 tRNA-splicing endonuclease subunit Sen2 isoform X7
-
XM_054348035.1 → XP_054204010.1 tRNA-splicing endonuclease subunit Sen2 isoform X2
- UniProtKB/Swiss-Prot
- B7Z6K1, C9IZI7, G5E9Q3, Q8NCE0, Q8WTW7, Q9BPU7
-
XM_054348039.1 → XP_054204014.1 tRNA-splicing endonuclease subunit Sen2 isoform X5
-
XM_054348033.1 → XP_054204008.1 tRNA-splicing endonuclease subunit Sen2 isoform X1
- UniProtKB/TrEMBL
-
A0A7P0T914
-
XM_054348042.1 → XP_054204017.1 tRNA-splicing endonuclease subunit Sen2 isoform X8
RNA
-
XR_008486816.1 RNA Sequence
-
XR_008486814.1 RNA Sequence
-
XR_008486822.1 RNA Sequence
-
XR_008486811.1 RNA Sequence
-
XR_008486815.1 RNA Sequence
-
XR_008486812.1 RNA Sequence
-
XR_008486810.1 RNA Sequence
-
XR_008486819.1 RNA Sequence
-
XR_008486813.1 RNA Sequence
-
XR_008486821.1 RNA Sequence
-
XR_008486820.1 RNA Sequence
-
XR_008486829.1 RNA Sequence
-
XR_008486823.1 RNA Sequence
-
XR_008486826.1 RNA Sequence
-
XR_008486824.1 RNA Sequence
-
XR_008486828.1 RNA Sequence
-
XR_008486825.1 RNA Sequence
-
XR_008486827.1 RNA Sequence
-
XR_008486830.1 RNA Sequence
-
XR_008486818.1 RNA Sequence
-
XR_008486817.1 RNA Sequence
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001145395.1: Suppressed sequence
- Description
- NM_001145395.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.