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    Ift25 intraflagellar transport 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685284, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ift25provided by RGD
    Official Full Name
    intraflagellar transport 25provided by RGD
    Primary source
    RGD:1596413
    See related
    EnsemblRapid:ENSRNOG00000010241 AllianceGenome:RGD:1596413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hspb11
    Summary
    Predicted to be involved in kidney development; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Orthologous to human IFT25 (intraflagellar transport 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 73.1), Lung (RPKM 58.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift25 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127264450..127291225)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122035588..122062421)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126856128..126882913)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene transmembrane protein 59 Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene iodothyronine deiodinase 1 Neighboring gene uncharacterized LOC134486960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Liu H, et al. Biol Reprod, 2017 May 1. PMID 28430876, Free PMC Article
    2. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
    3. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Keady BT, et al. Dev Cell, 2012 May 15. PMID 22595669, Free PMC Article
    4. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article
    5. Characterization of mouse IFT complex B. Follit JA, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19253336, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187878

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    NOT involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within left/right axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 25 homolog
    Names
    Hspb11 heat shock protein family B (small), member 11
    heat shock protein beta-11
    heat shock protein family B (small), member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131002.1 → NP_001124474.1  intraflagellar transport protein 25 homolog

      See identical proteins and their annotated locations for NP_001124474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162011
      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467
      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    2. NM_001429184.1 → NP_001416113.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467

    3. NM_001429185.1 → NP_001416114.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467

    4. NM_001429186.1 → NP_001416115.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127264450..127291225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763899.4 → XP_008762121.1  intraflagellar transport protein 25 homolog isoform X3

      See identical proteins and their annotated locations for XP_008762121.1

      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467
      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    2. XM_006238524.5 → XP_006238586.3  intraflagellar transport protein 25 homolog isoform X1

      Related
      ENSRNOP00000054174.4, ENSRNOT00000057362.6

    3. XM_063288427.1 → XP_063144497.1  intraflagellar transport protein 25 homolog isoform X4

    4. XM_006238530.4 → XP_006238592.1  intraflagellar transport protein 25 homolog isoform X3

      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    5. XM_039110786.2 → XP_038966714.1  intraflagellar transport protein 25 homolog isoform X3

      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    6. XM_039110787.2 → XP_038966715.1  intraflagellar transport protein 25 homolog isoform X3

      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467
      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    7. XM_017593635.3 → XP_017449124.1  intraflagellar transport protein 25 homolog isoform X3

      UniProtKB/TrEMBL
      A0A9K3Y7X2, B1WC57, D4A467
      Conserved Domains (1) summary
      pfam00754
      Location:19 → 125
      F5_F8_type_C; F5/8 type C domain

    8. XM_063288426.1 → XP_063144496.1  intraflagellar transport protein 25 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K664
      Related
      ENSRNOP00000073693.1, ENSRNOT00000080701.3

    9. XM_017593632.3 → XP_017449121.1  intraflagellar transport protein 25 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K664
      Conserved Domains (1) summary
      pfam00754
      Location:29 → 135
      F5_F8_type_C; F5/8 type C domain
    Nucleotide Protein Strain
    Heading Accession and Version

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