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    Fbxl6 F-box and leucine-rich repeat protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362941, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Fbxl6provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 6provided by RGD
    Primary source
    RGD:1359687
    See related
    EnsemblRapid:ENSRNOG00000025497 AllianceGenome:RGD:1359687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and entrainment of circadian clock by photoperiod. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL6 (F-box and leucine rich repeat protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 68.4), Kidney (RPKM 58.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl6 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110140243..110143176, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108259097..108262528, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117602056..117604954, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 2 Neighboring gene transfer RNA proline (anticodon AGG) 52 Neighboring gene transmembrane protein 249 Neighboring gene uncharacterized LOC134479929 Neighboring gene uncharacterized LOC134479928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a family of human F-box proteins. Cenciarelli C, et al. Curr Biol, 1999 Oct 21. PMID 10531035
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95310

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005563.1 → NP_001005563.1  F-box/LRR-repeat protein 6

      See identical proteins and their annotated locations for NP_001005563.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082108
      UniProtKB/TrEMBL
      A0A8I6G6V1, A6HSA6, F7FE66, Q641W5
      Related
      ENSRNOP00000035719.3, ENSRNOT00000035199.6
      Conserved Domains (3) summary
      cd09293
      Location:171 → 390
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:105 → 155
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110140243..110143176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079548.2 → XP_038935476.1  F-box/LRR-repeat protein 6 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:207 → 323
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:105 → 152
      F-box-like

    2. XM_039079549.2 → XP_038935477.1  F-box/LRR-repeat protein 6 isoform X3

      UniProtKB/TrEMBL
      A6HSA7
      Conserved Domains (2) summary
      cd09293
      Location:118 → 269
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:35 → 60
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_039079547.2 → XP_038935475.1  F-box/LRR-repeat protein 6 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:207 → 327
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:105 → 152
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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