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    Hsh2d hematopoietic SH2 domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360518, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Hsh2dprovided by RGD
    Official Full Name
    hematopoietic SH2 domain containingprovided by RGD
    Primary source
    RGD:2321939
    See related
    EnsemblRapid:ENSRNOG00000023614 AllianceGenome:RGD:2321939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Predicted to be located in cytosol and mitochondrion. Orthologous to human HSH2D (hematopoietic SH2 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 58.2), Thymus (RPKM 34.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsh2d in Genome Data Viewer
    Location:
    16p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17664548..17686976, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17630519..17649932, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19336400..19349868, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene family with sequence similarity 32, member A Neighboring gene calcium and integrin binding family member 3 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene uncharacterized LOC134482463 Neighboring gene tropomyosin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The adaptor protein HSH2 attenuates apoptosis in response to ligation of the B cell antigen receptor complex on the B lymphoma cell line, WEHI-231. Herrin BR, et al. J Biol Chem, 2005 Feb 4. PMID 15569688
    2. Cloning and characterization of ALX, an adaptor downstream of CD28. Greene TA, et al. J Biol Chem, 2003 Nov 14. PMID 12960172
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hematopoietic SH2 domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271328.1 → NP_001258257.1  hematopoietic SH2 domain-containing protein

      See identical proteins and their annotated locations for NP_001258257.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6K9Q2, D3ZRF7
      Related
      ENSRNOP00000037214.3, ENSRNOT00000038494.7
      Conserved Domains (1) summary
      cl15255
      Location:26 → 127
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17664548..17686976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094088.2 → XP_038950016.1  hematopoietic SH2 domain-containing protein isoform X4

      Conserved Domains (1) summary
      cl15255
      Location:26 → 127
      SH2; Src homology 2 (SH2) domain

    2. XM_039094087.2 → XP_038950015.1  hematopoietic SH2 domain-containing protein isoform X3

      Conserved Domains (1) summary
      cl15255
      Location:26 → 127
      SH2; Src homology 2 (SH2) domain

    3. XM_006252795.5 → XP_006252857.1  hematopoietic SH2 domain-containing protein isoform X1

      Conserved Domains (1) summary
      cl15255
      Location:26 → 127
      SH2; Src homology 2 (SH2) domain

    4. XM_039094086.2 → XP_038950014.1  hematopoietic SH2 domain-containing protein isoform X2

      Conserved Domains (1) summary
      cl15255
      Location:1 → 47
      SH2; Src homology 2 (SH2) domain

    5. XM_039094085.2 → XP_038950013.1  hematopoietic SH2 domain-containing protein isoform X2

      Conserved Domains (1) summary
      cl15255
      Location:1 → 47
      SH2; Src homology 2 (SH2) domain

    RNA

    1. XR_005494527.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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