ssl-1 Helicase ssl-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ssl-1
Gene description: Helicase ssl-1
Locus tag: CELE_Y111B2A.22
See related: AllianceGenome:WB:WBGene00007027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity and histone binding activity. Involved in negative regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of Swr1 complex. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to several human genes including SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ssl-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (12714566..12744721)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Helicase ssl-1

NP_001255179.1

Partially confirmed by transcript evidence

NP_001255180.1

Partially confirmed by transcript evidence

NP_001367265.1

Partially confirmed by transcript evidence

NP_001367266.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12714566..12744721

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268250.2 → NP_001255179.1 Helicase ssl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255179.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E0R7L4, E0R7L5, E0R7L6, Q6Q9H2, Q9NEL2

Conserved Domains (5) summary

COG5167
Location:249 → 376

VID27; Protein involved in vacuole import and degradation [Intracellular trafficking and secretion]

cd00046
Location:578 → 717

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:561 → 847

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1187 → 1301

Helicase_C; Helicase conserved C-terminal domain

pfam07529
Location:231 → 296

HSA; HSA
NM_001268251.3 → NP_001255180.1 Helicase ssl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255180.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NEL2

Conserved Domains (5) summary

COG5167
Location:249 → 376

VID27; Protein involved in vacuole import and degradation [Intracellular trafficking and secretion]

cd00046
Location:578 → 717

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:561 → 847

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1187 → 1301

Helicase_C; Helicase conserved C-terminal domain

pfam07529
Location:231 → 296

HSA; HSA
NM_001379967.1 → NP_001367266.1 Helicase ssl-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

PLN03142
Location:226 → 705

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

pfam09606
Location:1832 → 2213

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18793
Location:1037 → 1166

SF2_C_SNF; C-terminal helicase domain of the SNF family helicases

cd18003
Location:412 → 634

DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP

pfam07529
Location:85 → 150

HSA
NM_001379968.1 → NP_001367265.1 Helicase ssl-1 [Caenorhabditis elegans]

Status: REVIEWED