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    pgp-5 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 181276, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pgp-5
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00003999
    Locus tag
    CELE_C05A9.1
    See related
    AllianceGenome:WB:WBGene00003999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in several processes, including defense response to bacterium; response to nematicide; and stress response to cadmium ion. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pgp-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (10854216..10859297, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene ncRNA Neighboring gene P-GlycoProtein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Burkholderia pseudomallei kills Caenorhabditis elegans through virulence mechanisms distinct from intestinal lumen colonization. Ooi SK, et al. Virulence, 2012 Oct 1. PMID 23076282, Free PMC Article
    2. Ecotoxicogenomic analysis of stress induced on Caenorhabditis elegans in heavy metal contaminated soil after nZVI treatment. Fajardo C, et al. Chemosphere, 2020 Sep. PMID 32957299
    3. Intoxication vs. infection: a decade of studying Burkholderia pseudomallei virulence in a simple infection model. Day SR, et al. Virulence, 2012 Oct 1. PMID 23211680, Free PMC Article
    4. Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin. Ardelli BF, et al. Vet Parasitol, 2013 Jan 31. PMID 23062691
    5. WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans. Snoek BL, et al. Database (Oxford), 2020 Jan 1. PMID 31960906, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nematicide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    P-GlycoProtein related
    NP_001257116.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence
    NP_001257117.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10854216..10859297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270187.3 → NP_001257116.1  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17645
      Conserved Domains (3) summary
      cd03249
      Location:374 → 611
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:27 → 1241
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      cl00549
      Location:41 → 322
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001270188.3 → NP_001257117.1  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ78
      Conserved Domains (3) summary
      cd03249
      Location:282 → 519
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:1 → 1149
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      cl00549
      Location:1 → 230
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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