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    PRKACB protein kinase cAMP-activated catalytic subunit beta [ Homo sapiens (human) ]

    Gene ID: 5567, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PRKACBprovided by HGNC
    Official Full Name
    protein kinase cAMP-activated catalytic subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:9381
    See related
    Ensembl:ENSG00000142875 MIM:176892; AllianceGenome:HGNC:9381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAFD2; PKACB; PKA C-beta
    Summary
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRKACB in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84078079..84238498)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (83918534..84078964)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84543762..84704181)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene TTLL7 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1013 Neighboring gene uncharacterized LOC124904205 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84543332-84543857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1015 Neighboring gene TXN2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1016 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:84621187-84622386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84689847-84690648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:84690649-84691448 Neighboring gene Sharpr-MPRA regulatory region 3408 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:84720292-84720890 Neighboring gene NANOG hESC enhancer GRCh37_chr1:84724969-84725470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1248 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene NEDD8 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
      Title: Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
    2. PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
      Title: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
    3. Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
      Title: Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
    4. Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
      Title: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
    5. Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC.
      Title: Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC.
    6. Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.
      Title: Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.
    7. The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
      Title: The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
    8. PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
      Title: PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
    9. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
      Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
    10. MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB.
      Title: MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cardioacrofacial dysplasia 2
    MedGen: C5436886 OMIM: 619143 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
    env The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling PubMed
    env Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity PubMed
    Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
    Tat tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
    tat HIV-1 Tat-peptide(48-60) inhibits protein kinase C alpha and protein kinase A in a concentration-dependent manner PubMed
    tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
    Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
    Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
    capsid gag cAMP-dependent protein kinase is incorporated into HIV-1 virions, interacts with and phosphorylates the HIV-1 Capsid protein, and regulates HIV-1 infectivity PubMed
    matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
    gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9320, MGC41879, DKFZp586F2323, DKFZp781I2452

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in high-density lipoprotein particle assembly TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal water homeostasis TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cAMP-dependent protein kinase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase catalytic subunit beta
    Names
    protein kinase A catalytic subunit beta
    protein kinase, cAMP-dependent, beta catalytic subunit
    protein kinase, cAMP-dependent, catalytic, beta
    NP_001229786.1
    NP_001229787.1
    NP_001229788.1
    NP_001229789.1
    NP_001229790.1
    NP_001229791.1
    NP_001287844.1
    NP_001287845.1
    NP_001287846.1
    NP_001362489.1
    NP_001362490.1
    NP_001362491.1
    NP_001362492.1
    NP_001362493.1
    NP_001362494.1
    NP_001362498.1
    NP_001362500.1
    NP_001362501.1
    NP_001362502.1
    NP_001362503.1
    NP_001362504.1
    NP_001362505.1
    NP_001362506.1
    NP_001362507.1
    NP_001362508.1
    NP_001362509.1
    NP_001362510.1
    NP_002722.1
    NP_891993.1
    NP_997461.1
    XP_005271077.1
    XP_016857200.1
    XP_016857205.1
    XP_016857206.1
    XP_047280637.1
    XP_054193534.1
    XP_054193535.1
    XP_054193536.1
    XP_054193537.1
    XP_054193538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029728.1 RefSeqGene

      Range
      71210..165437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242857.3 → NP_001229786.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

      See identical proteins and their annotated locations for NP_001229786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' exon structure, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK296482, AL450063, BX641026, DC322547
      Consensus CDS
      CCDS55609.1
      UniProtKB/TrEMBL
      A8K8B9
      Related
      ENSP00000401252.2, ENST00000446538.5
      Conserved Domains (1) summary
      cd14209
      Location:49 → 338
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    2. NM_001242858.3 → NP_001229787.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

      See identical proteins and their annotated locations for NP_001229787.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' exon structure, compared to variant 1. The encoded isoform (5, also known as Cbeta3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK304375, AL450063, BX641026, DC322547
      Consensus CDS
      CCDS72813.1
      UniProtKB/TrEMBL
      A8K8B9
      Related
      ENSP00000481980.1, ENST00000610703.4
      Conserved Domains (1) summary
      cd14209
      Location:30 → 319
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    3. NM_001242859.3 → NP_001229788.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

      See identical proteins and their annotated locations for NP_001229788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' exon structure, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL450063, BX641026
      Consensus CDS
      CCDS55610.1
      UniProtKB/TrEMBL
      A8K8B9
      Related
      ENSP00000390906.2, ENST00000436133.6
      Conserved Domains (1) summary
      cd14209
      Location:46 → 335
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    4. NM_001242860.3 → NP_001229789.1  cAMP-dependent protein kinase catalytic subunit beta isoform 7

      See identical proteins and their annotated locations for NP_001229789.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' exon structure, compared to variant 1. The encoded isoform (7, also known as Cbeta4abc) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB209189, AL450063, BX641026, DA188681
      Consensus CDS
      CCDS72815.1
      UniProtKB/TrEMBL
      A8K8B9
      Related
      ENSP00000479722.1, ENST00000614872.4
      Conserved Domains (1) summary
      cd14209
      Location:48 → 337
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    5. NM_001242861.3 → NP_001229790.1  cAMP-dependent protein kinase catalytic subunit beta isoform 8

      See identical proteins and their annotated locations for NP_001229790.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' exon structure, compared to variant 1. The encoded isoform (8, also known as Cbeta4ab) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK091420, AL450063, BX641026, DA188681
      Consensus CDS
      CCDS55611.1
      UniProtKB/TrEMBL
      A8K8B9
      Related
      ENSP00000378315.2, ENST00000394839.6
      Conserved Domains (1) summary
      cd14209
      Location:45 → 301
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    6. NM_001242862.3 → NP_001229791.1  cAMP-dependent protein kinase catalytic subunit beta isoform 9

      See identical proteins and their annotated locations for NP_001229791.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' exon structure, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK316115, AL450063, BX641026, DA228647
      Consensus CDS
      CCDS72816.1
      UniProtKB/TrEMBL
      A0A087WVC4, B7ZA00
      Related
      ENSP00000479339.1, ENST00000610457.2
      Conserved Domains (1) summary
      cd14209
      Location:29 → 318
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    7. NM_001300915.2 → NP_001287844.1  cAMP-dependent protein kinase catalytic subunit beta isoform 10

      See identical proteins and their annotated locations for NP_001287844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (10) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AA761973, BC016285, BX369882, BX647515, DA188681
      Consensus CDS
      CCDS72814.1
      UniProtKB/TrEMBL
      B1APG3
      Related
      ENSP00000359714.1, ENST00000370680.5
      Conserved Domains (1) summary
      cl21453
      Location:48 → 264
      PKc_like; Protein Kinases, catalytic domain

    8. NM_001300916.2 → NP_001287845.1  cAMP-dependent protein kinase catalytic subunit beta isoform 11

      See identical proteins and their annotated locations for NP_001287845.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 3' exon structure, compared to variant 1. The encoded isoform (11) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA761973, BC016285, BM905428, BX369882, DC418574
      UniProtKB/Swiss-Prot
      P22694
      Conserved Domains (1) summary
      cl21453
      Location:89 → 302
      PKc_like; Protein Kinases, catalytic domain

    9. NM_001300917.2 → NP_001287846.1  cAMP-dependent protein kinase catalytic subunit beta isoform 12

      See identical proteins and their annotated locations for NP_001287846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (12) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AA761973, BC016285, BI598037, BX369882, DC322547
      Consensus CDS
      CCDS72812.1
      UniProtKB/TrEMBL
      B1APF8, B1APF9
      Related
      ENSP00000359718.1, ENST00000370684.5
      Conserved Domains (1) summary
      cl21453
      Location:30 → 243
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001375560.1 → NP_001362489.1  cAMP-dependent protein kinase catalytic subunit beta isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:45 → 334
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    11. NM_001375561.1 → NP_001362490.1  cAMP-dependent protein kinase catalytic subunit beta isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:40 → 329
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    12. NM_001375562.1 → NP_001362491.1  cAMP-dependent protein kinase catalytic subunit beta isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:41 → 330
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    13. NM_001375563.1 → NP_001362492.1  cAMP-dependent protein kinase catalytic subunit beta isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:38 → 327
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    14. NM_001375564.1 → NP_001362493.1  cAMP-dependent protein kinase catalytic subunit beta isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:37 → 326
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    15. NM_001375565.1 → NP_001362494.1  cAMP-dependent protein kinase catalytic subunit beta isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      A8K8B9
      Conserved Domains (1) summary
      cd14209
      Location:29 → 318
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    16. NM_001375569.1 → NP_001362498.1  cAMP-dependent protein kinase catalytic subunit beta isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL450063
      Conserved Domains (1) summary
      cl21453
      Location:49 → 262
      PKc_like; Protein Kinases, catalytic domain

    17. NM_001375571.1 → NP_001362500.1  cAMP-dependent protein kinase catalytic subunit beta isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL450063
      Conserved Domains (1) summary
      cl21453
      Location:48 → 261
      PKc_like; Protein Kinases, catalytic domain

    18. NM_001375572.1 → NP_001362501.1  cAMP-dependent protein kinase catalytic subunit beta isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APF8
      Conserved Domains (1) summary
      cl21453
      Location:46 → 262
      PKc_like; Protein Kinases, catalytic domain

    19. NM_001375573.1 → NP_001362502.1  cAMP-dependent protein kinase catalytic subunit beta isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APF8
      Conserved Domains (1) summary
      cl21453
      Location:45 → 261
      PKc_like; Protein Kinases, catalytic domain

    20. NM_001375574.1 → NP_001362503.1  cAMP-dependent protein kinase catalytic subunit beta isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APG2
      Conserved Domains (1) summary
      cl21453
      Location:40 → 256
      PKc_like; Protein Kinases, catalytic domain

    21. NM_001375575.1 → NP_001362504.1  cAMP-dependent protein kinase catalytic subunit beta isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APG2
      Conserved Domains (1) summary
      cl21453
      Location:45 → 258
      PKc_like; Protein Kinases, catalytic domain

    22. NM_001375576.1 → NP_001362505.1  cAMP-dependent protein kinase catalytic subunit beta isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL359504, AL450063
      UniProtKB/TrEMBL
      K7ERP6
      Conserved Domains (1) summary
      cl21453
      Location:42 → 258
      PKc_like; Protein Kinases, catalytic domain

    23. NM_001375577.1 → NP_001362506.1  cAMP-dependent protein kinase catalytic subunit beta isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APG2
      Conserved Domains (1) summary
      cl21453
      Location:40 → 253
      PKc_like; Protein Kinases, catalytic domain

    24. NM_001375578.1 → NP_001362507.1  cAMP-dependent protein kinase catalytic subunit beta isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APF8
      Conserved Domains (1) summary
      cl21453
      Location:30 → 246
      PKc_like; Protein Kinases, catalytic domain

    25. NM_001375579.1 → NP_001362508.1  cAMP-dependent protein kinase catalytic subunit beta isforom 29

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APG1
      Conserved Domains (1) summary
      cl21453
      Location:29 → 245
      PKc_like; Protein Kinases, catalytic domain

    26. NM_001375580.1 → NP_001362509.1  cAMP-dependent protein kinase catalytic subunit beta isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL450063
      UniProtKB/TrEMBL
      B1APG1
      Related
      ENSP00000399326.1, ENST00000417530.5
      Conserved Domains (1) summary
      cl21453
      Location:29 → 242
      PKc_like; Protein Kinases, catalytic domain

    27. NM_001375581.1 → NP_001362510.1  cAMP-dependent protein kinase catalytic subunit beta isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL450063
      Conserved Domains (1) summary
      cl21453
      Location:49 → 265
      PKc_like; Protein Kinases, catalytic domain

    28. NM_002731.4 → NP_002722.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

      See identical proteins and their annotated locations for NP_002722.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' exon structure, compared to variant 1. The encoded isoform (2, also known as Cbeta1) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC035058, BX537705, BX641026, HY160843, M34181
      Consensus CDS
      CCDS691.1
      UniProtKB/Swiss-Prot
      B1APG4, B4DKB0, B4E2Q1, P22694, Q14VH1, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0, Q96B09
      UniProtKB/TrEMBL
      A8K8B9, B2RB89, D3DT10
      Related
      ENSP00000359723.2, ENST00000370689.6
      Conserved Domains (1) summary
      cd14209
      Location:42 → 331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    29. NM_182948.4 → NP_891993.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

      See identical proteins and their annotated locations for NP_891993.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Cbeta2).
      Source sequence(s)
      BC035058, BX485407, BX537705, BX641026, M34181
      Consensus CDS
      CCDS693.1
      UniProtKB/TrEMBL
      B4E2L0
      Related
      ENSP00000359719.3, ENST00000370685.7
      Conserved Domains (1) summary
      cd14209
      Location:89 → 378
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    30. NM_207578.3 → NP_997461.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

      See identical proteins and their annotated locations for NP_997461.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in both the 5' and 3' exon structures, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AA761973, BC016285, BX369882, HY160843
      Consensus CDS
      CCDS692.1
      UniProtKB/TrEMBL
      K7ERP6
      Related
      ENSP00000359722.3, ENST00000370688.7
      Conserved Domains (1) summary
      cl21453
      Location:42 → 255
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      84078079..84238498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271020.3 → XP_005271077.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005271077.1

      Conserved Domains (1) summary
      cl21453
      Location:89 → 305
      PKc_like; Protein Kinases, catalytic domain

    2. XM_047424681.1 → XP_047280637.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

    3. XM_017001711.2 → XP_016857200.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

      UniProtKB/TrEMBL
      B1APF8
      Conserved Domains (1) summary
      cl21453
      Location:46 → 259
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017001716.2 → XP_016857205.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

      UniProtKB/TrEMBL
      B1APF8
      Related
      ENSP00000392275.1, ENST00000432111.5

    5. XM_017001717.2 → XP_016857206.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

      UniProtKB/TrEMBL
      B1APG2
      Related
      ENSP00000397175.1, ENST00000413538.5

    RNA

    1. XR_007061945.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      83918534..84078964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337559.1 → XP_054193534.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

    2. XM_054337560.1 → XP_054193535.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

    3. XM_054337561.1 → XP_054193536.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

    4. XM_054337562.1 → XP_054193537.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

    5. XM_054337563.1 → XP_054193538.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22694.2 GenPept UniProtKB/Swiss-Prot:P22694

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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