ddx39ab DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx39abprovided by ZNC
Official Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2902
See related: Ensembl:ENSDARG00000015111 AllianceGenome:ZFIN:ZDB-GENE-040426-2902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ddx39; ddx39b; fc16a02; zgc:55433; zgc:85646; wu:fc16a02
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Is expressed in several structures, including eye; heart tube; immature eye; liver; and trunk musculature. Orthologous to human DDX39A (DExD-box helicase 39A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (5619056..5644059, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (5709135..5734138, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ddx39ab plays an essential role in establishment of the proper epigenetic status during differentiation of multiple cell lineages.
Title: The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI657667 (e-PCR)
- UniSTS:206103

fb57e04.x1 (e-PCR)
- UniSTS:190775

fb57e04.x1 (e-PCR)
- UniSTS:190776

LF138SP6 (e-PCR)
- UniSTS:527997

fc16a02.x1 (e-PCR)
- UniSTS:192763

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b

NP_998142.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212977.2 → NP_998142.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab

See identical proteins and their annotated locations for NP_998142.1

Status: VALIDATED

Source sequence(s)

BC128804, FP101915

UniProtKB/TrEMBL

A1A5T8, Q803W0

Related

ENSDARP00000010925.9, ENSDART00000019957.10

Conserved Domains (3) summary

PTZ00424
Location:19 → 417

PTZ00424; helicase 45; Provisional

cd00079
Location:261 → 389

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:46 → 249

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...