hprt1 hypoxanthine phosphoribosyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hprt1provided by ZNC
Official Full Name: hypoxanthine phosphoribosyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1918
See related: Ensembl:ENSDARG00000008884 AllianceGenome:ZFIN:ZDB-GENE-040426-1918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56221; zgc:86608; id:ibd1344; id:ibd5108; wu:fc10g09
Summary: Predicted to enable hypoxanthine phosphoribosyltransferase activity and magnesium ion binding activity. Predicted to be involved in hypoxanthine metabolic process and purine-containing compound salvage. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be located in cytoplasm. Is expressed in several structures, including digestive system; immature eye; midbrain; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (31509900..31520855)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (31169589..31180541)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc10g09.x1 (e-PCR)
- UniSTS:187739

hprt1 (e-PCR)
- UniSTS:238286

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables guanine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in guanine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hypoxanthine-guanine phosphoribosyltransferase

NP_998151.1

EC 2.4.2.8

XP_005173261.1

EC 2.4.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212986.2 → NP_998151.1 hypoxanthine-guanine phosphoribosyltransferase

See identical proteins and their annotated locations for NP_998151.1

Status: VALIDATED

Source sequence(s)

BX511227, EH497665

UniProtKB/TrEMBL

F6NPH6, F8W5D2, Q7ZV49

Related

ENSDARP00000111738.2, ENSDART00000124499.4

Conserved Domains (1) summary

cl00309
Location:6 → 218

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

31509900..31520855

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173204.4 → XP_005173261.1 hypoxanthine-guanine phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

Q7ZV49

Conserved Domains (1) summary

cl00309
Location:6 → 218

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain