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    ddx1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 556790, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ddx1provided by ZNC
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box helicase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-215
    See related
    Ensembl:ENSDARG00000032117 AllianceGenome:ZFIN:ZDB-GENE-041001-215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-214k9.2; si:dkey-161f12.1
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and exonuclease activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (33175190..33189652)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (33272311..33286773)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene LRAT domain containing 1 Neighboring gene NBAS subunit of NRZ tethering complex Neighboring gene uncharacterized LOC110438181 Neighboring gene MYCN proto-oncogene, bHLH transcription factor Neighboring gene SMEK homolog 1, suppressor of mek1 (Dictyostelium)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp. Mojzesz M, et al. Fish Shellfish Immunol, 2020 Sep. PMID 32526283
    2. Genome-wide association and functional follow-up reveals new loci for kidney function. Pattaro C, et al. PLoS Genet, 2012. PMID 22479191, Free PMC Article
    3. Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection. Widziolek M, et al. Dev Comp Immunol, 2021 Mar. PMID 33242567
    4. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Li RA, et al. Blood, 2016 Dec 29. PMID 27827822
    5. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX1
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
    NP_001184253.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197324.1 → NP_001184253.1  ATP-dependent RNA helicase DDX1

      Status: PROVISIONAL

      Source sequence(s)
      BX005358, BX649472
      UniProtKB/TrEMBL
      A0A8M1NW84, F1R2L8
      Related
      ENSDARP00000008636.7, ENSDART00000023963.10
      Conserved Domains (5) summary
      smart00487
      Location:238 → 439
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:1 → 62
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:493 → 609
      Helicase_C; Helicase conserved C-terminal domain
      cd12873
      Location:93 → 245
      SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1
      cl21455
      Location:266 → 426
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      33175190..33189652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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