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    inppl1b inositol polyphosphate phosphatase-like 1b [ Danio rerio (zebrafish) ]

    Gene ID: 368433, updated on 2-Nov-2024

    Summary

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    Official Symbol
    inppl1bprovided by ZNC
    Official Full Name
    inositol polyphosphate phosphatase-like 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-75
    See related
    Ensembl:ENSDARG00000001442 AllianceGenome:ZFIN:ZDB-GENE-030616-75
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    inppl1; ship-2b; si:bz46j2.7; si:rp71-46j2.7
    Summary
    Predicted to enable inositol-polyphosphate 5-phosphatase activity. Predicted to be involved in negative regulation of insulin-like growth factor receptor signaling pathway and regulation of immune response. Predicted to act upstream of or within cell adhesion; immune system process; and phosphatidylinositol dephosphorylation. Predicted to be located in nuclear speck. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See inppl1b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (32793586..32824407, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32453272..32484093, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-143l19.3 Neighboring gene SRY-box transcription factor 3 Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene arrestin 3b, retinal (X-arrestin) Neighboring gene NFKB repressing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions. Inaba Y, et al. Elife, 2020 Sep 7. PMID 32894222, Free PMC Article
    2. The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. Lam PY, et al. J Cell Sci, 2012 Nov 1. PMID 22946052, Free PMC Article
    3. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Jurynec MJ, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20616095, Free PMC Article
    4. Expression of three P4-phospholipid flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Hawkey-Noble A, et al. Gene Expr Patterns, 2020 Jun. PMID 32344036
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo.
      Title: The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate phosphatase-like 1b
    Names
    INPPL-1B
    SH2 domain-containing inositol 5'-phosphatase 2B
    SH2 domain-containing inositol phosphatase 2B
    SH2-domain-containing inositol 5-phosphatase 2b
    inositol polyphosphate phosphatase-like 1
    inositol polyphosphate phosphatase-like protein 1B
    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B
    ship2b
    NP_001034224.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039135.2 → NP_001034224.2  inositol polyphosphate phosphatase-like 1b

      Status: VALIDATED

      Source sequence(s)
      BC163188
      UniProtKB/Swiss-Prot
      Q2I6J0
      UniProtKB/TrEMBL
      A0A8M1N8H7
      Related
      ENSDARP00000142592.1, ENSDART00000172791.2
      Conserved Domains (4) summary
      smart00454
      Location:1165 → 1218
      SAM; Sterile alpha motif
      cd10343
      Location:2 → 104
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
      cl00490
      Location:404 → 707
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
      cl15755
      Location:1165 → 1221
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      32793586..32824407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004500.1: Suppressed sequence

      Description
      NM_001004500.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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