prss23 serine protease 23 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prss23provided by ZNC
Official Full Name: serine protease 23provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9149
See related: Ensembl:ENSDARG00000055786 AllianceGenome:ZFIN:ZDB-GENE-030131-9149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb01h12; wu:fb01h12
Summary: Predicted to enable serine-type endopeptidase activity and serine-type exopeptidase activity. Acts upstream of or within atrioventricular valve development; endocardium morphogenesis; and regulation of Notch signaling pathway. Is expressed in atrioventricular canal; atrium; cardiac ventricle; and pectoral fin. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (30802467..30808358, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (30462035..30468042, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

deficiency of PRSS23 in zebrafish embryos inhibited the initiation of the endothelial to mesenchymal transition which resulted in atrioventricular canal malformation.
Title: PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk97c04.x1 (e-PCR)
- UniSTS:201810

fb01h12.y1 (e-PCR)
- UniSTS:189801

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: serine protease 23; serine protease 23-like

Names: protease, serine, 23

XP_001338393.1

EC 3.4.21.-

XP_692384.2

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423236.1 → NP_001410165.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

CT573152

UniProtKB/TrEMBL

A0A140LH88, A0A8M1PSA1

Related

ENSDARP00000142618.1, ENSDART00000173262.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

30802467..30808358 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001338357.7 → XP_001338393.1 serine protease 23-like

See identical proteins and their annotated locations for XP_001338393.1

UniProtKB/TrEMBL

A0A140LH88, A0A8M1PSA1

Conserved Domains (1) summary

cl21584
Location:142 → 245

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_687292.8 → XP_692384.2 serine protease 23-like

UniProtKB/TrEMBL

F1R3E8

Conserved Domains (1) summary

cl21584
Location:142 → 245

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...