grinab glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grinabprovided by ZNC
Official Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1367
See related: Ensembl:ENSDARG00000052746 AllianceGenome:ZFIN:ZDB-GENE-040426-1367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grina; tmbim3; zgc:64102
Summary: Acts upstream of or within negative regulation of apoptotic process and negative regulation of neuron death. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in eye; head; nervous system; and spinal cord. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (53489685..53516433)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (53601360..53629606)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308611.1 → NP_001295540.1 glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)

See identical proteins and their annotated locations for NP_001295540.1

Status: VALIDATED

Source sequence(s)

CR759845, EH541500, EH562651

UniProtKB/TrEMBL

A0A8M2B4U7, F1QKT8

Related

ENSDARP00000069140.4, ENSDART00000074653.6

Conserved Domains (1) summary

cd10428
Location:119 → 333

LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis