cygb1 cytoglobin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cygb1provided by ZNC
Official Full Name: cytoglobin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020513-1
See related: Ensembl:ENSDARG00000099371 AllianceGenome:ZFIN:ZDB-GENE-020513-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cygb; wu:fb77d07; wu:fb93a03; zgc:109806
Summary: Enables nitrite reductase activity and oxygen binding activity. Acts upstream of or within neural crest cell development; regulation of neural crest cell differentiation; and response to cadmium ion. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including blood; brain; digestive system; head; and trunk neural crest. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (6639788..6668176)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (6753956..6782336)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response.
Title: The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response.
A globin-family protein, Cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish.
Title: A globin-family protein, Cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish.
The results uncover unexpected properties of zebrafish cytoglobin 1 and reveal the pivotal role of cytoglobin 1 in the transition of heme cytoglobin 1 from six-coordinate to five-coordinate oxygen carriers and nitrite reductases.
Title: Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins.

Submit: New GeneRIF Correction

General gene information

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Markers

fb93a03.x1 (e-PCR)
- UniSTS:203525

fc23d08.x1 (e-PCR)
- UniSTS:193148

fb77d07.x1 (e-PCR)
- UniSTS:191363

fb77d07.x1 (e-PCR)
- UniSTS:191364

AI584387 (e-PCR)
- UniSTS:206246

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide dioxygenase activity, heme protein as donor	ISS Inferred from Sequence or Structural Similarity more info
enables nitrite reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoglobin-1

Names: cyt; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; superoxide dismutase CYGB

NP_694484.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.