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    odc1 ornithine decarboxylase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 114426, updated on 1-Jun-2024

    Summary

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    Official Symbol
    odc1provided by ZNC
    Official Full Name
    ornithine decarboxylase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010816-1
    See related
    Ensembl:ENSDARG00000007377 AllianceGenome:ZFIN:ZDB-GENE-010816-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    odc; fc54f04; fi06d08; CHUNP6922; wu:fc54f04; wu:fi06d08
    Summary
    Predicted to enable ornithine decarboxylase activity. Acts upstream of or within eye photoreceptor cell development. Predicted to be active in cytoplasm. Is expressed in neuromast and ovary. Orthologous to several human genes including ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See odc1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (51743921..51757548)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (51654886..51668513)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene nucleolar protein 10 Neighboring gene si:ch211-168d23.3 Neighboring gene exonuclease 3'-5' domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of ornithine decarboxylase gene from flounder (Paralichthys olivaceus). Lee JH, et al. Mar Biotechnol (NY), 2004 Sep-Oct. PMID 15791490
    2. Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio). Hascilowicz T, et al. Biochim Biophys Acta, 2002 Oct 11. PMID 12393184
    3. RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo. Herzog C, et al. Biol Open, 2020 May 4. PMID 32366533, Free PMC Article
    4. Fluid dynamics during bleb formation in migrating cells in vivo. Goudarzi M, et al. PLoS One, 2019. PMID 30807602, Free PMC Article
    5. Zebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression. Nogare DE, et al. Dev Dyn, 2007 Dec. PMID 17969147, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular cloning of species-specific enzyme and its antizyme-mediated degradation
      Title: Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within eye photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase
    NP_571876.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131801.2 → NP_571876.1  ornithine decarboxylase

      See identical proteins and their annotated locations for NP_571876.1

      Status: PROVISIONAL

      Source sequence(s)
      AB069857
      UniProtKB/TrEMBL
      A0A2R8RVZ8, F8W5Z9, Q9DGJ4
      Related
      ENSDARP00000124918.1, ENSDART00000149039.3
      Conserved Domains (2) summary
      cd00622
      Location:37 → 409
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 409
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      51743921..51757548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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