usp12a ubiquitin specific peptidase 12a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: usp12aprovided by ZNC
Official Full Name: ubiquitin specific peptidase 12aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060228-3
See related: Ensembl:ENSDARG00000078109 AllianceGenome:ZFIN:ZDB-GENE-060228-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: usp12; sb:eu882; wu:fi09d12
Summary: Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in protein deubiquitination and regulation of protein stability. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21600320..21620275, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21455146..21475101, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 12A

Names: deubiquitinating enzyme 12A; ubiquitin specific peptidase 12; ubiquitin thioesterase 12A; ubiquitin thiolesterase 12A; ubiquitin-specific-processing protease 12A

NP_001077025.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083556.1 → NP_001077025.1 ubiquitin carboxyl-terminal hydrolase 12A

See identical proteins and their annotated locations for NP_001077025.1

Status: PROVISIONAL

Source sequence(s)

BC115286

UniProtKB/Swiss-Prot

A4FUN7

Related

ENSDARP00000103890.2, ENSDART00000112670.3

Conserved Domains (2) summary

cd02663
Location:40 → 368

Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:38 → 367

UCH; Ubiquitin carboxyl-terminal hydrolase