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    st8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553210, updated on 2-Nov-2024

    Summary

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    Official Symbol
    st8sia1provided by ZNC
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051005-1
    See related
    Ensembl:ENSDARG00000098221 AllianceGenome:ZFIN:ZDB-GENE-051005-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    siat 8A; zgc:158304
    Summary
    Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to act upstream of or within protein glycosylation and sphingolipid metabolic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including corpuscles of Stannius; forebrain neural plate; kidney; nervous system; and unfertilized egg. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See st8sia1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (26303610..26322836, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (26314412..26333638, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491555 Neighboring gene uncharacterized LOC137491557 Neighboring gene troponin I, skeletal, slow d Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of oligosialylation in zebrafish. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18704683
    2. Molecular evolution and expression of zebrafish St8SiaIII, an alpha-2,8-sialyltransferase involved in myotome development. Bentrop J, et al. Dev Dyn, 2008 Mar. PMID 18265011
    3. Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. Chang LY, et al. Int J Mol Sci, 2019 Jan 31. PMID 30709055, Free PMC Article
    4. Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18642128
    5. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
    Names
    alpha-2,8-sialyltransferase ST8Sia I
    NP_001075101.1
    NP_001314770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081632.1 → NP_001075101.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001075101.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      BC128837
      UniProtKB/TrEMBL
      A0A8M1ND26, A1A5W4
      Related
      ENSDARP00000134208.1, ENSDART00000161687.2
      Conserved Domains (1) summary
      pfam00777
      Location:72 → 145
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001327841.1 → NP_001314770.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CT573128, CU137645
      UniProtKB/TrEMBL
      A3KQF4, Q6KC13
      Related
      ENSDARP00000136671.1, ENSDART00000170709.2
      Conserved Domains (1) summary
      pfam00777
      Location:72 → 323
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      26303610..26322836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394557.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      3538..5225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395233.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      3538..5225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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