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    hipk3b homeodomain interacting protein kinase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 569156, updated on 28-Oct-2024

    Summary

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    Official Symbol
    hipk3bprovided by ZNC
    Official Full Name
    homeodomain interacting protein kinase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-82
    See related
    Ensembl:ENSDARG00000062082 AllianceGenome:ZFIN:ZDB-GENE-030131-82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd59e05; zeh1150; hm:zeh1150; wu:fd59e05; si:dkey-261h15.1
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hipk3b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (27904515..27995061)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (27926221..28017423)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 18b Neighboring gene IQ motif containing G Neighboring gene KIAA1549-like b Neighboring gene uncharacterized LOC137488290

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. Zheng D, et al. BMC Genomics, 2010 Oct 11. PMID 20937081, Free PMC Article
    2. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 3
    NP_001073628.1
    XP_005159231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080159.2 → NP_001073628.1  homeodomain-interacting protein kinase 3

      See identical proteins and their annotated locations for NP_001073628.1

      Status: PROVISIONAL

      Source sequence(s)
      BX908394, BX908791
      UniProtKB/TrEMBL
      A0A8M1NCP8, Q1LUZ7
      Related
      ENSDARP00000150978.1, ENSDART00000191835.1
      Conserved Domains (2) summary
      smart00220
      Location:252 → 580
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:251 → 580
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      27904515..27995061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159174.5 → XP_005159231.1  homeodomain-interacting protein kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_005159231.1

      UniProtKB/TrEMBL
      A0A8M1NCP8, Q1LUZ7
      Related
      ENSDARP00000119096.1, ENSDART00000142336.2
      Conserved Domains (2) summary
      smart00220
      Location:252 → 580
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:251 → 580
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
    Nucleotide Protein Strain
    Heading Accession and Version

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