cst14b.1 cystatin 14b, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cst14b.1provided by ZNC
Official Full Name: cystatin 14b, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-189
See related: Ensembl:ENSDARG00000117133 AllianceGenome:ZFIN:ZDB-GENE-061013-189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153129
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome; peeling skin syndrome 4; and progressive myoclonus epilepsy 1A. Orthologous to several human genes including CSTB (cystatin B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (4522353..4532909, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (4081465..4092016, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb10f04.x1 (e-PCR)
- UniSTS:190007

fb10f04.x1 (e-PCR)
- UniSTS:190008

AI397367 (e-PCR)
- UniSTS:206656

fa09f11.r1 (e-PCR)
- UniSTS:189569

fc15c03.x1 (e-PCR)
- UniSTS:192720

fc15c03.x1 (e-PCR)
- UniSTS:192721

fa92a02.x1 (e-PCR)
- UniSTS:189652

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin 14b, tandem duplicate 1

Names: cystatin 14 b, tandem duplicated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077274.1 → NP_001070742.1 cystatin 14b, tandem duplicate 1

See identical proteins and their annotated locations for NP_001070742.1

Status: PROVISIONAL

Source sequence(s)

BC124645

UniProtKB/TrEMBL

Q08BN2

Conserved Domains (1) summary

cl09238
Location:7 → 78

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

4522353..4532909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301150.4 → XP_009299425.1 cystatin 14b, tandem duplicate 1 isoform X1

UniProtKB/TrEMBL

A0A2R8QDV2, A0A8M3ARV8

Related

ENSDARP00000151877.1, ENSDART00000192398.1

Conserved Domains (1) summary

cl09238
Location:7 → 78

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.