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    dpp9 dipeptidyl-peptidase 9 [ Danio rerio (zebrafish) ]

    Gene ID: 768170, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dpp9provided by ZNC
    Official Full Name
    dipeptidyl-peptidase 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-777
    See related
    Ensembl:ENSDARG00000052606 AllianceGenome:ZFIN:ZDB-GENE-061013-777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7145318; zgc:152900
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Acts upstream of or within regulation of inflammatory response. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dpp9 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (47677180..47722065)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (47688187..47733073)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, eta 2a Neighboring gene si:ch211-251b21.1 Neighboring gene si:ch211-243p7.3 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Harapas CR, et al. Sci Immunol, 2022 Sep 16. PMID 36112693, Free PMC Article
    2. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
      Title: DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 9
    NP_001070781.2
    XP_005172542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077313.2 → NP_001070781.2  dipeptidyl peptidase 9

      Status: VALIDATED

      Source sequence(s)
      CR855877, CU499311
      UniProtKB/Swiss-Prot
      A0A2R8QP51, A0A8M1NBI9
      Related
      ENSDARP00000156382.1, ENSDART00000192605.1
      Conserved Domains (3) summary
      COG1506
      Location:526 → 885
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:684 → 885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:171 → 592
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      47677180..47722065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172485.4 → XP_005172542.1  dipeptidyl peptidase 9 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJR8
      Related
      ENSDARP00000153678.1, ENSDART00000187320.1
      Conserved Domains (3) summary
      COG1506
      Location:525 → 884
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:683 → 884
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:171 → 591
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2R8QP51.1 GenPept UniProtKB/Swiss-Prot:A0A2R8QP51

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