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    pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [ Danio rerio (zebrafish) ]

    Gene ID: 571356, updated on 28-Oct-2024

    Summary

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    Official Symbol
    pik3c2aprovided by ZNC
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030328-39
    See related
    Ensembl:ENSDARG00000060841 AllianceGenome:ZFIN:ZDB-GENE-030328-39
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb156; wu:fc02a04; si:dkey-24l11.7
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within angiogenesis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Used to study cataract. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3c2a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (27001112..27073137)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (27018705..27090752)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488287 Neighboring gene reticulocalbin 2 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene pleckstrin homology domain containing, family A member 7a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. Lai JG, et al. PLoS One, 2014. PMID 25171174, Free PMC Article
    2. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Gulluni F, et al. Science, 2021 Dec 10. PMID 34882480, Free PMC Article
    3. Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Pereiro P, et al. Antiviral Res, 2017 Sep. PMID 28789986
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
      Title: PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
    Names
    phosphoinositide-3-kinase, class 2, alpha polypeptide
    XP_021323497.1
    XP_021330106.1
    XP_068071009.1
    XP_068075023.1
    XP_068075457.1
    XP_700029.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      27001112..27073137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214908.1 → XP_068071009.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    2. XM_021467822.2 → XP_021323497.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M9P1D7, F6NMW9
      Related
      ENSDARP00000080566.5, ENSDART00000086131.6
      Conserved Domains (7) summary
      cd07289
      Location:1422 → 1530
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:675 → 846
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1559 → 1680
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      pfam00794
      Location:420 → 507
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl00271
      Location:866 → 1032
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl21453
      Location:1039 → 1391
      PKc_like; Protein Kinases, catalytic domain
      cl25716
      Location:137 → 207
      Amelogenin; Amelogenin

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395030.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      181438..256038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694937.9 → XP_700029.5  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A2R8QSP1, A0A8N7T897
      Conserved Domains (7) summary
      cd07289
      Location:1422 → 1530
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:675 → 846
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1559 → 1680
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      pfam00794
      Location:420 → 507
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl00271
      Location:866 → 1032
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl21453
      Location:1039 → 1391
      PKc_like; Protein Kinases, catalytic domain
      cl25716
      Location:137 → 207
      Amelogenin

    2. XM_068218922.1 → XP_068075023.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395342.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      525246..584833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219356.1 → XP_068075457.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    2. XM_021474431.2 → XP_021330106.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q547
      Conserved Domains (5) summary
      cd04012
      Location:675 → 846
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      pfam00794
      Location:420 → 507
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl00271
      Location:866 → 1032
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl21453
      Location:1039 → 1179
      PKc_like; Protein Kinases, catalytic domain
      cl25716
      Location:137 → 207
      Amelogenin
    Nucleotide Protein Strain
    Heading Accession and Version

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