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    stxbp5a syntaxin binding protein 5a (tomosyn) [ Danio rerio (zebrafish) ]

    Gene ID: 556789, updated on 28-Oct-2024

    Summary

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    Official Symbol
    stxbp5aprovided by ZNC
    Official Full Name
    syntaxin binding protein 5a (tomosyn)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-161
    See related
    Ensembl:ENSDARG00000002656 AllianceGenome:ZFIN:ZDB-GENE-041001-161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-279m15.2
    Summary
    Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See stxbp5a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31748648..31905966, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31845909..32003287, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488589 Neighboring gene uronyl 2-sulfotransferase a Neighboring gene SAM and SH3 domain containing 1a Neighboring gene uncharacterized LOC137488662 Neighboring gene androglobin Neighboring gene RAB32a, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Zhu H, et al. J Exp Zool B Mol Dev Evol, 2022 Jul. PMID 35226401
    2. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein 5a
    Names
    stxbp5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099981.2 → NP_001093451.1  syntaxin-binding protein 5a

      Status: PROVISIONAL

      Source sequence(s)
      BX649312, BX927258, CT573242
      UniProtKB/TrEMBL
      A0A8M1NDY6, Q5RGD1
      Related
      ENSDARP00000114105.1, ENSDART00000142806.3
      Conserved Domains (5) summary
      COG2319
      Location:42 → 270
      WD40; WD40 repeat [General function prediction only]
      cd15893
      Location:1061 → 1121
      R-SNARE_STXBP5; SNARE domain of STXBP5
      pfam08366
      Location:272 → 379
      LLGL; LLGL2
      sd00039
      Location:57 → 90
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 275
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      31748648..31905966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294730.4 → XP_009293005.1  syntaxin-binding protein 5a isoform X3

      UniProtKB/TrEMBL
      A0A8M3ALK2
      Conserved Domains (5) summary
      COG2319
      Location:42 → 270
      WD40; WD40 repeat [General function prediction only]
      cd15893
      Location:1028 → 1088
      R-SNARE_STXBP5; SNARE domain of STXBP5
      pfam08366
      Location:272 → 379
      LLGL; LLGL2
      sd00039
      Location:57 → 90
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 275
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_009294728.4 → XP_009293003.1  syntaxin-binding protein 5a isoform X2

      UniProtKB/TrEMBL
      A0A8M3B457
      Conserved Domains (5) summary
      COG2319
      Location:42 → 270
      WD40; WD40 repeat [General function prediction only]
      cd15893
      Location:1059 → 1119
      R-SNARE_STXBP5; SNARE domain of STXBP5
      pfam08366
      Location:272 → 379
      LLGL; LLGL2
      sd00039
      Location:57 → 90
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 275
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_009294727.4 → XP_009293002.1  syntaxin-binding protein 5a isoform X1

      UniProtKB/TrEMBL
      A0A8M3AKV9
      Conserved Domains (5) summary
      COG2319
      Location:42 → 270
      WD40; WD40 repeat [General function prediction only]
      cd15893
      Location:1075 → 1135
      R-SNARE_STXBP5; SNARE domain of STXBP5
      pfam08366
      Location:272 → 379
      LLGL; LLGL2
      sd00039
      Location:57 → 90
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 275
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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