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    faf2 Fas associated factor family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 497596, updated on 28-Oct-2024

    Summary

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    Official Symbol
    faf2provided by ZNC
    Official Full Name
    Fas associated factor family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-312
    See related
    Ensembl:ENSDARG00000052374 AllianceGenome:ZFIN:ZDB-GENE-050208-312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7148063; zgc:194819
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in lipid droplet. Predicted to be active in endoplasmic reticulum. Orthologous to human FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See faf2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (50994519..51014292, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (45843287..45863060, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene cadherin related family member 2 Neighboring gene ring finger protein 44 Neighboring gene HIG1 hypoxia inducible domain family, member 2A Neighboring gene clathrin, light chain B Neighboring gene PDZ and LIM domain 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio). Shihana F, et al. Liver Int, 2023 Nov. PMID 37650211
    2. Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Grepper D, et al. Mol Metab, 2023 Feb. PMID 36642092, Free PMC Article
    3. Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model. Ma JX, et al. Front Immunol, 2018. PMID 29942316, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FAS-associated factor 2
    Names
    UBX domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128680.1 → NP_001122152.1  FAS-associated factor 2

      See identical proteins and their annotated locations for NP_001122152.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163084
      UniProtKB/TrEMBL
      B3DID0
      Related
      ENSDARP00000033367.6, ENSDART00000029797.9
      Conserved Domains (3) summary
      cd01774
      Location:358 → 442
      Faf1_like2_UBX; Faf1 ike-2 UBX domain
      cd02991
      Location:154 → 269
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cd14414
      Location:15 → 52
      UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      50994519..51014292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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