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    cdk11b cyclin dependent kinase 11B [ Danio rerio (zebrafish) ]

    Gene ID: 494103, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cdk11bprovided by ZNC
    Official Full Name
    cyclin dependent kinase 11Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-74
    See related
    Ensembl:ENSDARG00000102546 AllianceGenome:ZFIN:ZDB-GENE-041212-74
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cdc2l1; im:7142267; zgc:101589
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within smoothened signaling pathway. Predicted to be active in nucleus. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See cdk11b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53948192..53960349, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53615204..53627412, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene matrix metallopeptidase 23ba Neighboring gene si:ch73-236j9.2 Neighboring gene solute carrier family 35 member E2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Evangelista M, et al. Sci Signal, 2008 Sep 30. PMID 18827223
    2. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 11B
    Names
    cell division cycle 2-like 1 (PITSLRE proteins)
    NP_001008646.1
    XP_009302607.1
    XP_009302610.1
    XP_068079035.1
    XP_068079036.1
    XP_068079037.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008646.1 → NP_001008646.1  cyclin-dependent kinase 11B

      See identical proteins and their annotated locations for NP_001008646.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086709
      UniProtKB/TrEMBL
      Q5PRD1
      Related
      ENSDARP00000138340.1, ENSDART00000160074.2
      Conserved Domains (2) summary
      cd07843
      Location:437 → 728
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:440 → 730
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      53948192..53960349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222936.1 → XP_068079037.1  cyclin-dependent kinase 11B isoform X5

    2. XM_009304335.4 → XP_009302610.1  cyclin-dependent kinase 11B isoform X4

      UniProtKB/TrEMBL
      A0A8M3AVM5
      Conserved Domains (2) summary
      cd07843
      Location:387 → 678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    3. XM_068222935.1 → XP_068079036.1  cyclin-dependent kinase 11B isoform X3

    4. XM_068222934.1 → XP_068079035.1  cyclin-dependent kinase 11B isoform X2

    5. XM_009304332.4 → XP_009302607.1  cyclin-dependent kinase 11B isoform X1

      UniProtKB/TrEMBL
      A0A8M3BC62
      Conserved Domains (2) summary
      cd07843
      Location:444 → 735
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:447 → 737
      PLN00009; cyclin-dependent kinase A; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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