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    muc5.1 mucin 5.1, oligomeric mucus/gel-forming [ Danio rerio (zebrafish) ]

    Gene ID: 100148804, updated on 28-Oct-2024

    Summary

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    Official Symbol
    muc5.1provided by ZNC
    Official Full Name
    mucin 5.1, oligomeric mucus/gel-formingprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120822-1
    See related
    Ensembl:ENSDARG00000070331 AllianceGenome:ZFIN:ZDB-GENE-120822-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    muc5ac
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in esophagus; gill lamella; intestine; and pharynx. Human ortholog(s) of this gene implicated in asthma; dry eye syndrome; lung disease (multiple); and urinary bladder cancer. Orthologous to several human genes including MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See muc5.1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8356823..8400124)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8279772..8323056)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mucin-5AC-like Neighboring gene intestinal mucin-like protein Neighboring gene mucin 5.2 Neighboring gene FA complementation group I Neighboring gene polymerase (DNA directed), gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Lang T, et al. Mol Biol Evol, 2016 Aug. PMID 27189557, Free PMC Article
    2. Zebrafish as a model to study live mucus physiology. Jevtov I, et al. Sci Rep, 2014 Oct 17. PMID 25323747, Free PMC Article
    3. Role of the melanocortin system in zebrafish skin physiology. Leal E, et al. Fish Shellfish Immunol, 2022 Nov. PMID 36150411
    4. Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis. Oehlers SH, et al. Dis Model Mech, 2012 Jul. PMID 22563081, Free PMC Article
    5. Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Udayangani RMC, et al. Fish Shellfish Immunol, 2017 Jul. PMID 28479399

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mucin-2
    Names
    muc
    muc5c
    muc5l
    mucin 5AC, oligomeric mucus/gel-forming

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      8356823..8400124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470622.2 → XP_021326297.1  mucin-2

      UniProtKB/TrEMBL
      A0A8M9P6P6, X1WBL9
      Related
      ENSDARP00000127611.1, ENSDART00000153708.3
      Conserved Domains (8) summary
      smart00041
      Location:5198 → 5274
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00216
      Location:867 → 1025
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1063 → 1135
      C8; This domain contains 8 conserved cysteine residues
      pfam05375
      Location:848 → 874
      Pacifastin_I; Pacifastin inhibitor (LCMII)
      pfam00094
      Location:420 → 571
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:324 → 380
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:4818 → 4880
      C8; C8 domain
      pfam13330
      Location:1386 → 1476
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    Nucleotide Protein Strain
    Heading Accession and Version

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