rangrf RAN guanine nucleotide release factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rangrfprovided by ZNC
Official Full Name: RAN guanine nucleotide release factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-143
See related: Ensembl:ENSDARG00000098786 AllianceGenome:ZFIN:ZDB-GENE-060526-143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Mog1; RanGNRF; zmynd19; si:ch211-268m12.6
Summary: Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; small GTPase binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including heart contraction; heart development; and regulation of heart looping. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in blastomere; brain; eye; fin; and heart. Orthologous to human RANGRF (RAN guanine nucleotide release factor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (54280142..54294086)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (53633511..53647490)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and heart rate.
Title: Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane depolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ran guanine nucleotide release factor

Names: ran-binding protein MOG1; zinc finger, MYND domain containing 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.