U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    syn1 synapsin I [ Danio rerio (zebrafish) ]

    Gene ID: 570672, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    syn1provided by ZNC
    Official Full Name
    synapsin Iprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081105-93
    See related
    Ensembl:ENSDARG00000060368 AllianceGenome:ZFIN:ZDB-GENE-081105-93
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-90n12.3
    Summary
    Predicted to enable ATP binding activity and actin binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to be located in Golgi apparatus and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See syn1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (31119302..31148580)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (31109903..31139093)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 20 member 1a Neighboring gene vestigial like 4 like Neighboring gene glycosyltransferase family 92 protein F13G3.3-like Neighboring gene glycosyltransferase family 92 protein F13G3.3-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior. Goode C, et al. J Comp Neurol, 2021 Jun. PMID 33491202, Free PMC Article
    2. Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Rodriguez RS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Jun. PMID 24667760
    3. Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant. Shimomura S, et al. J Biochem, 2010 May. PMID 20097902
    4. Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio). Cheng Y, et al. Ecotoxicol Environ Saf, 2015 Feb. PMID 25463847
    5. Late recruitment of synapsin to nascent synapses is regulated by Cdk5. Easley-Neal C, et al. Cell Rep, 2013 Apr 25. PMID 23602570, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    synapsin-1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126437.2 → NP_001119909.1  synapsin-1

      Status: PROVISIONAL

      Source sequence(s)
      CR376723
      UniProtKB/TrEMBL
      A0A8N1Z0Y3, B0UXI4
      Related
      ENSDARP00000115298.1, ENSDART00000136578.2
      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; Synapsin, N-terminal domain
      pfam10581
      Location:1 → 32
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 394
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      31119302..31148580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167178.4 → XP_005167235.1  synapsin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEL9
      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; Synapsin, N-terminal domain
      pfam10581
      Location:1 → 32
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 394
      ATP-grasp_4; ATP-grasp domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394732.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      352928..381699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools