ano1a anoctamin 1, calcium activated chloride channel a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ano1aprovided by ZNC
Official Full Name: anoctamin 1, calcium activated chloride channel aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-121127-3
See related: Ensembl:ENSDARG00000102335 AllianceGenome:ZFIN:ZDB-GENE-121127-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ano1
Summary: Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in fast muscle cell and slow muscle cell. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (54322648..54449665, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (54052996..54170389, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that Cl(-) influx through calcium activated chloride channel anoctamin-1 (ANO1) plays an essential role in restricting the width of skeletal-muscle action potentials (APs) by accelerating the repolarisation phase.
Title: Ca(2+)-activated Cl(-) channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration.
The present results also indicate that the Ano1 antiserum is a selective marker of interstitial cells of Cajal - like cells in the zebrafish intestine revealing a 3-dimensional network.
Title: Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anoctamin-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161590.1 → NP_001155062.1 anoctamin-1a

Status: PROVISIONAL

Source sequence(s)

CR318608, CU928764

UniProtKB/TrEMBL

A0A8M1NT27

Conserved Domains (2) summary

pfam04547
Location:315 → 889

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:53 → 312

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

54322648..54449665 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068222213.1 → XP_068078314.1 anoctamin-1a isoform X2
XM_068222212.1 → XP_068078313.1 anoctamin-1a isoform X1
XM_017356841.3 → XP_017212330.1 anoctamin-1a isoform X5

UniProtKB/TrEMBL

A0A8M6Z1H3

Related

ENSDARP00000138095.1, ENSDART00000167905.2
XM_009303473.4 → XP_009301748.1 anoctamin-1a isoform X4

UniProtKB/TrEMBL

A0A8M3AUJ5

Conserved Domains (2) summary

pfam04547
Location:315 → 892

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:53 → 312

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_009303471.4 → XP_009301746.1 anoctamin-1a isoform X3

UniProtKB/TrEMBL

A0A8M3AUL7

Conserved Domains (2) summary

pfam04547
Location:353 → 930

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:91 → 350

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin