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    rps7 ribosomal protein S7 [ Danio rerio (zebrafish) ]

    Gene ID: 393725, updated on 28-Oct-2024

    Summary

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    Official Symbol
    rps7provided by ZNC
    Official Full Name
    ribosomal protein S7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1718
    See related
    Ensembl:ENSDARG00000042566 AllianceGenome:ZFIN:ZDB-GENE-040426-1718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73216
    Summary
    Predicted to be a structural constituent of ribosome. Acts upstream of or within chordate embryonic development; hemopoiesis; and regulation of cell cycle. Predicted to be located in several cellular components, including centrosome; nucleus; and ribosome. Predicted to be part of cytosolic small ribosomal subunit and small-subunit processome. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 8. Orthologous to human RPS7 (ribosomal protein S7). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rps7 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (30372352..30377169, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (30469473..30474290, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488661 Neighboring gene uncharacterized LOC137488588 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene allantoicase Neighboring gene ribonuclease H1 Neighboring gene myelin transcription factor 1-like, a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway. Heijnen HF, et al. PLoS Genet, 2014. PMID 24875531, Free PMC Article
    2. A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization. Pereboom TC, et al. Blood, 2011 Nov 17. PMID 21921046
    3. Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. MacInnes AW, et al. Proc Natl Acad Sci U S A, 2008 Jul 29. PMID 18641120, Free PMC Article
    4. Many ribosomal protein genes are cancer genes in zebrafish. Amsterdam A, et al. PLoS Biol, 2004 May. PMID 15138505, Free PMC Article
    5. Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish. Duan J, et al. Int J Biochem Cell Biol, 2011 Aug. PMID 21550419

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC73216

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS7
    Names
    40S ribosomal protein S7
    NP_957046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200752.1 → NP_957046.1  small ribosomal subunit protein eS7

      See identical proteins and their annotated locations for NP_957046.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059562
      UniProtKB/Swiss-Prot
      P62084
      Related
      ENSDARP00000109497.2, ENSDART00000126229.4
      Conserved Domains (1) summary
      pfam01251
      Location:14 → 191
      Ribosomal_S7e; Ribosomal protein S7e

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      30372352..30377169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62084.1 GenPept UniProtKB/Swiss-Prot:P62084

    Gene LinkOut

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