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    huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 559439, updated on 28-Oct-2024

    Summary

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    Official Symbol
    huwe1provided by ZNC
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-387
    See related
    Ensembl:ENSDARG00000016782 AllianceGenome:ZFIN:ZDB-GENE-081104-387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu595; sb:eu633; sb:eu703; si:dkey-242a8.2
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See huwe1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    84
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28489936..28568980)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28563367..28642437)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882861 Neighboring gene transmembrane protein 107 like Neighboring gene microRNA let7g-2 Neighboring gene microRNA let7h Neighboring gene L1 cell adhesion molecule, paralog a Neighboring gene RIB43A domain with coiled-coils 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Frohnhöfer HG, et al. Biol Open, 2016 Jun 15. PMID 27215328, Free PMC Article
    2. Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Lee YR, et al. Nat Commun, 2020 Jul 23. PMID 32703943, Free PMC Article
    3. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    HECT, UBA and WWE domain containing 1
    NP_001352583.1
    NP_001352584.1
    XP_001923900.2
    XP_005162335.1
    XP_005162337.1
    XP_005162338.1
    XP_005162339.1
    XP_009295237.1
    XP_009295238.1
    XP_068072873.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365654.1 → NP_001352583.1  E3 ubiquitin-protein ligase HUWE1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX664745
      UniProtKB/TrEMBL
      A0A8M9Q812
      Conserved Domains (7) summary
      cd00078
      Location:4214 → 4567
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3054 → 3167
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2830 → 3145
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    2. NM_001365655.1 → NP_001352584.1  E3 ubiquitin-protein ligase HUWE1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX664745
      UniProtKB/TrEMBL
      A0A8M3AVJ4
      Conserved Domains (7) summary
      cd00078
      Location:4156 → 4509
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3054 → 3167
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2830 → 3145
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      28489936..28568980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162278.5 → XP_005162335.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_005162335.1

      UniProtKB/TrEMBL
      A0A8M9Q812
      Conserved Domains (7) summary
      cd00078
      Location:4214 → 4567
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3054 → 3167
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2830 → 3145
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    2. XM_009296963.4 → XP_009295238.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3AVJ4
      Conserved Domains (7) summary
      cd00078
      Location:4156 → 4509
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3054 → 3167
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2830 → 3145
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    3. XM_001923865.7 → XP_001923900.2  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PX07
      Related
      ENSDARP00000118265.1, ENSDART00000146990.2
      Conserved Domains (7) summary
      cd00078
      Location:4201 → 4554
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3041 → 3154
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:2807 → 3091
      Atrophin-1; Atrophin-1 family

    4. XM_005162281.5 → XP_005162338.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B950
      Conserved Domains (7) summary
      cd00078
      Location:4213 → 4566
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3053 → 3166
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2829 → 3144
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    5. XM_005162280.5 → XP_005162337.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PE41
      Conserved Domains (7) summary
      cd00078
      Location:4213 → 4566
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3053 → 3166
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2829 → 3144
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    6. XM_005162282.5 → XP_005162339.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B9D5
      Conserved Domains (7) summary
      cd00078
      Location:4182 → 4535
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1657 → 1718
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3022 → 3135
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2798 → 3113
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    7. XM_009296962.3 → XP_009295237.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_009295237.1

      UniProtKB/TrEMBL
      A0A8M9Q812
      Conserved Domains (7) summary
      cd00078
      Location:4214 → 4567
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1389 → 1428
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1689 → 1750
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 847
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3054 → 3167
      DUF4414; Domain of unknown function (DUF4414)
      cl26247
      Location:2830 → 3145
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    8. XM_068216772.1 → XP_068072873.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395155.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      451507..529261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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