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    mc5rb melanocortin 5b receptor [ Danio rerio (zebrafish) ]

    Gene ID: 286835, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mc5rbprovided by ZNC
    Official Full Name
    melanocortin 5b receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021223-4
    See related
    Ensembl:ENSDARG00000054946 AllianceGenome:ZFIN:ZDB-GENE-021223-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mc5br; mc5ra; zMC5b; zgc:194217
    Summary
    Enables protein heterodimerization activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in ovary and testis. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mc5rb in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30578937..30594683, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30624739..30636760, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene lamin A Neighboring gene melanocortin 2 receptor Neighboring gene family with sequence similarity 210 member Ab Neighboring gene low density lipoprotein receptor class A domain containing 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Liao S, et al. Fish Physiol Biochem, 2019 Feb. PMID 30288633
    2. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Zhu M, et al. J Mol Endocrinol, 2018 Oct 1. PMID 30400043
    3. Creation of a genetic model of obesity in a teleost. Song Y, et al. FASEB J, 2007 Jul. PMID 17341684
    4. Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs. Kumar A, et al. PLoS One, 2011. PMID 21850219, Free PMC Article
    5. Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). Sánchez E, et al. Am J Physiol Regul Integr Comp Physiol, 2009 May. PMID 19225141, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables melanocortin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables melanocortin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    melanocortin 5b receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173280.1 → NP_775387.1  melanocortin 5b receptor

      See identical proteins and their annotated locations for NP_775387.1

      Status: PROVISIONAL

      Source sequence(s)
      AY078991
      UniProtKB/TrEMBL
      Q8JGW1
      Related
      ENSDARP00000071694.3, ENSDART00000077226.4
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:45 → 169
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      30578937..30594683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158169.5 → XP_005158226.1  melanocortin 5b receptor isoform X1

      See identical proteins and their annotated locations for XP_005158226.1

      UniProtKB/TrEMBL
      A0A8M2B532, F1Q9X6
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:45 → 169
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version

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