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    camk2d1 calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445208, updated on 28-Oct-2024

    Summary

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    Official Symbol
    camk2d1provided by ZNC
    Official Full Name
    calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-121
    See related
    Ensembl:ENSDARG00000043010 AllianceGenome:ZFIN:ZDB-GENE-040801-121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    camk2db; wu:fc54g06; zgc:101001; zgc:173815
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in regulation of neuronal synaptic plasticity; regulation of protein localization to plasma membrane; and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm; neuron projection; and postsynaptic density. Is expressed in brain; epidermis; hatching gland; trunk; and vertical myoseptum. Orthologous to human CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See camk2d1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (57725750..57880134)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (57423274..57577691)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene MAD2 mitotic arrest deficient-like 1 (yeast) Neighboring gene arylsulfatase family, member J Neighboring gene ankyrin 2b, neuronal Neighboring gene neutral sphingomyelinase (N-SMase) activation associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Rothschild SC, et al. Gene, 2020 Jun 5. PMID 32165308
    2. NMDA receptors on zebrafish Mauthner cells require CaMKII-α for normal development. Roy B, et al. Dev Neurobiol, 2015 Feb. PMID 25047640
    3. Differential expression of CaMK-II genes during early zebrafish embryogenesis. Rothschild SC, et al. Dev Dyn, 2007 Jan. PMID 17103413
    4. Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary. Chen H, et al. Aquat Toxicol, 2019 Nov. PMID 31518775
    5. The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry. Francescatto L, et al. Development, 2010 Aug. PMID 20630945

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC173815

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type II delta 1 chain
    Names
    caM kinase II subunit delta-B
    caM-kinase II delta-B chain
    caMK-II subunit delta-B
    calcium/calmodulin-dependent protein kinase (CaM kinase) II delta b
    calcium/calmodulin-dependent protein kinase type II delta-B chain
    NP_001003602.1
    NP_001108180.1
    XP_005166618.1
    XP_009301757.1
    XP_009301760.1
    XP_021333143.1
    XP_068078331.1
    XP_068078332.1
    XP_068078333.1
    XP_068078334.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003602.2 → NP_001003602.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 2

      See identical proteins and their annotated locations for NP_001003602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a coding region segment, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1.
      Source sequence(s)
      AI793833, BC077143, BC154189
      UniProtKB/Swiss-Prot
      A8WGM2, Q6DGS3
      Related
      ENSDARP00000119349.1, ENSDART00000142259.3
      Conserved Domains (3) summary
      smart00220
      Location:13 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:344 → 471
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    2. NM_001114708.2 → NP_001108180.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 1

      See identical proteins and their annotated locations for NP_001108180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC154189, BX901910, CN513429, CR392345, EB951992, EE714463
      UniProtKB/Swiss-Prot
      A8KBP0, A8WGM2, Q6DEH3, Q6DGS3
      Related
      ENSDARP00000131013.2, ENSDART00000166198.2
      Conserved Domains (3) summary
      smart00220
      Location:13 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:359 → 486
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      57725750..57880134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222230.1 → XP_068078331.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1

    2. XM_068222233.1 → XP_068078334.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X5

    3. XM_009303482.4 → XP_009301757.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X3

      UniProtKB/TrEMBL
      A0A8M3B4F8
      Conserved Domains (3) summary
      smart00220
      Location:13 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:459 → 586
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    4. XM_009303485.4 → XP_009301760.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X7

      UniProtKB/Swiss-Prot
      A8WGM2, Q6DGS3
      UniProtKB/TrEMBL
      A0A2U3TVF6, A0A8M3AUM3
      Related
      ENSDARP00000056465.6, ENSDART00000056466.8
      Conserved Domains (3) summary
      smart00220
      Location:13 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:359 → 486
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    5. XM_068222232.1 → XP_068078333.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X4

    6. XM_005166561.5 → XP_005166618.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X8

      UniProtKB/Swiss-Prot
      A8WGM2, Q6DGS3
      UniProtKB/TrEMBL
      A0A8M2BE13
      Conserved Domains (3) summary
      smart00220
      Location:13 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:344 → 471
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    7. XM_068222231.1 → XP_068078332.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X2

    8. XM_021477468.2 → XP_021333143.1  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X6

      UniProtKB/Swiss-Prot
      A8WGM2, Q6DGS3
      UniProtKB/TrEMBL
      A0A8M9Q1D8
      Conserved Domains (2) summary
      cd14086
      Location:11 → 302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:379 → 506
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DEH3.2 GenPept UniProtKB/Swiss-Prot:Q6DEH3

    Gene LinkOut

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