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    grm1a glutamate receptor, metabotropic 1a [ Danio rerio (zebrafish) ]

    Gene ID: 555576, updated on 28-Oct-2024

    Summary

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    Official Symbol
    grm1aprovided by ZNC
    Official Full Name
    glutamate receptor, metabotropic 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7893
    See related
    Ensembl:ENSDARG00000026796 AllianceGenome:ZFIN:ZDB-GENE-030131-7893
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj39d05; wu:fj39d05; si:ch211-51a19.1
    Summary
    Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See grm1a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (32047385..32112908, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (32144506..32209928, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene androglobin Neighboring gene RAB32a, member RAS oncogene family Neighboring gene CD164 molecule, sialomucin Neighboring gene centrosomal protein 57, like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio). Lüffe TM, et al. Front Mol Neurosci, 2022. PMID 35769333, Free PMC Article
    2. Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. Li J, et al. Sci Total Environ, 2022 Aug 25. PMID 35525365
    3. Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling. Chen Z, et al. Front Mol Neurosci, 2022. PMID 35909444, Free PMC Article
    4. Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). Haug MF, et al. J Comp Neurol, 2013 May 1. PMID 23047810
    5. Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. Huang YY, et al. PLoS One, 2012. PMID 22523578, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metabotropic glutamate receptor 1
    Names
    metabotropic glutamate receptor 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      32047385..32112908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002665739.6 → XP_002665785.3  metabotropic glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R9YJL7, A0A8M1RMJ3
      Related
      ENSDARP00000123024.2, ENSDART00000142653.4
      Conserved Domains (5) summary
      cd06374
      Location:48 → 523
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:617 → 850
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:89 → 497
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:534 → 583
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1110 → 1153
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    2. XM_009294784.4 → XP_009293059.1  metabotropic glutamate receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ATC9
      Conserved Domains (4) summary
      cd06374
      Location:48 → 523
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:617 → 850
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:89 → 497
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:534 → 583
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044788.1: Suppressed sequence

      Description
      NM_001044788.1: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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