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    pcca propionyl-CoA carboxylase subunit alpha [ Danio rerio (zebrafish) ]

    Gene ID: 437019, updated on 28-Oct-2024

    Summary

    Official Symbol
    pccaprovided by ZNC
    Official Full Name
    propionyl-CoA carboxylase subunit alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-246
    See related
    Ensembl:ENSDARG00000028982 AllianceGenome:ZFIN:ZDB-GENE-040718-246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb92g02; wu:fb92g02; zgc:100925
    Summary
    Predicted to enable propionyl-CoA carboxylase activity. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; optic tectum; and segmental plate. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    NEW
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    Genomic context

    See pcca in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (29862085..29953746)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (29058154..29149815)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 2 Neighboring gene zic family member 2 (odd-paired homolog, Drosophila) b Neighboring gene membrane-associated ring finger (C3HC4) 4a Neighboring gene im:7148405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables propionyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables propionyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    propionyl-CoA carboxylase alpha chain, mitochondrial
    Names
    propionyl CoA carboxylase, alpha polypeptide
    propionyl-Coenzyme A carboxylase, alpha polypeptide
    NP_001002746.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002746.2NP_001002746.1  propionyl-CoA carboxylase alpha chain, mitochondrial

      See identical proteins and their annotated locations for NP_001002746.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076408
      UniProtKB/TrEMBL
      Q6DGE2
      Related
      ENSDARP00000117212.1, ENSDART00000133905.3
      Conserved Domains (5) summary
      cd06850
      Location:643708
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      smart00878
      Location:378485
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      COG4770
      Location:44709
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
      pfam00289
      Location:44152
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02786
      Location:157363
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      29862085..29953746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394490.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      93053..184605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)